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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2007-6-26
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pubmed:abstractText |
Peripherin/rds (P/rds), the product of the retinal degeneration slow (rds) gene, is a tetraspanin protein that plays a pivotal role for photoreceptor outer segment (OS) structure and is involved in a broad spectrum of inherited retinal degenerations. P/rds interacts with the homologous protein rom-1, previously proposed to regulate P/rds function. The authors examined the significance of an intramembrane glutamic acid conserved in all P/rds proteins (and many other tetraspanins) but absent in all rom-1 orthologs.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2975-86
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17591862-Amino Acid Substitution,
pubmed-meshheading:17591862-Animals,
pubmed-meshheading:17591862-Blotting, Western,
pubmed-meshheading:17591862-COS Cells,
pubmed-meshheading:17591862-Cercopithecus aethiops,
pubmed-meshheading:17591862-Electroretinography,
pubmed-meshheading:17591862-Gene Expression Regulation,
pubmed-meshheading:17591862-Genotype,
pubmed-meshheading:17591862-Glutamic Acid,
pubmed-meshheading:17591862-Immunoprecipitation,
pubmed-meshheading:17591862-Intermediate Filament Proteins,
pubmed-meshheading:17591862-Membrane Glycoproteins,
pubmed-meshheading:17591862-Mice,
pubmed-meshheading:17591862-Mice, Inbred C57BL,
pubmed-meshheading:17591862-Mice, Transgenic,
pubmed-meshheading:17591862-Microscopy, Immunoelectron,
pubmed-meshheading:17591862-Morphogenesis,
pubmed-meshheading:17591862-Mutagenesis, Site-Directed,
pubmed-meshheading:17591862-Nerve Tissue Proteins,
pubmed-meshheading:17591862-Photoreceptor Cells, Vertebrate,
pubmed-meshheading:17591862-Retina,
pubmed-meshheading:17591862-Retinal Degeneration,
pubmed-meshheading:17591862-Transgenes
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pubmed:year |
2007
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pubmed:articleTitle |
An intramembrane glutamic acid governs peripherin/rds function for photoreceptor disk morphogenesis.
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pubmed:affiliation |
Eye Research Institute, Oakland University, Rochester, Michigan 48309, USA. goldberg@oakland.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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