17591791

Source:http://linkedlifedata.com/resource/pubmed/id/17591791

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0006013, umls-concept:C0020835, umls-concept:C0020964, umls-concept:C0035820
pubmed:issue	9
pubmed:dateCreated	2007-8-20
pubmed:abstractText	The genus Bordetella includes a group of closely related mammalian pathogens that cause a variety of respiratory diseases in a long list of animals (B. bronchiseptica) and whooping cough in humans (B. pertussis and B. parapertussis). While past research has examined how these pathogens are eliminated from the lower respiratory tract, the host factors that control and/or clear the bordetellae from the upper respiratory tract remain unclear. We hypothesized that immunoglobulin A (IgA), the predominant mucosal antibody isotype, would have a protective role against these mucosal pathogens. IgA(-/-) mice were indistinguishable from wild-type mice in their control and clearance of B. pertussis or B. parapertussis, suggesting that IgA is not crucial to immunity to these organisms. However, naïve and convalescent IgA(-/-) mice were defective in reducing the numbers of B. bronchiseptica in the upper respiratory tract compared to wild-type controls. Passively transferred serum from convalescent IgA(-/-) mice was not as effective as serum from convalescent wild-type mice in clearing this pathogen from the tracheae of naive recipient mice. IgA induced by B. bronchiseptica infection predominantly recognized lipopolysaccharide-containing O-antigen, and antibodies against O-antigen were important to bacterial clearance from the trachea. Since an IgA response contributes to the control of B. bronchiseptica infection of the upper respiratory tract, immunization strategies aimed at inducing B. bronchiseptica-specific IgA may be beneficial to preventing the spread of this bacterium among domestic animal populations.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/AI053075, http://linkedlifedata.com/resource/pubmed/grant/R01 AI053075-01A1, http://linkedlifedata.com/resource/pubmed/grant/R01 AI053075-02, http://linkedlifedata.com/resource/pubmed/grant/R01 AI053075-03, http://linkedlifedata.com/resource/pubmed/grant/R01 AI053075-04, http://linkedlifedata.com/resource/pubmed/grant/R01 AI053075-04S1, http://linkedlifedata.com/resource/pubmed/grant/R01 AI053075-05, http://linkedlifedata.com/resource/pubmed/grant/R01 GM083113-01
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0246127
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A, http://linkedlifedata.com/resource/pubmed/chemical/O Antigens
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0019-9567
pubmed:author	pubmed-author:GoebelElizabeth MEM, pubmed-author:HarvillEric TET, pubmed-author:KirimanjeswaraGirish SGS, pubmed-author:WolfeDaniel NDN
pubmed:issnType	Print
pubmed:volume	75
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	4416-22
pubmed:dateRevised	2011-8-1
pubmed:meshHeading	pubmed-meshheading:17591791-Animals, pubmed-meshheading:17591791-Antibody Formation, pubmed-meshheading:17591791-Bordetella, pubmed-meshheading:17591791-Bordetella Infections, pubmed-meshheading:17591791-Bordetella bronchiseptica, pubmed-meshheading:17591791-Bordetella parapertussis, pubmed-meshheading:17591791-Bordetella pertussis, pubmed-meshheading:17591791-Immunity, Innate, pubmed-meshheading:17591791-Immunoglobulin A, pubmed-meshheading:17591791-Lung Diseases, pubmed-meshheading:17591791-Mice, pubmed-meshheading:17591791-Mice, Inbred C57BL, pubmed-meshheading:17591791-Mice, Knockout, pubmed-meshheading:17591791-O Antigens, pubmed-meshheading:17591791-Respiratory Tract Infections, pubmed-meshheading:17591791-Trachea
pubmed:year	2007
pubmed:articleTitle	Comparative role of immunoglobulin A in protective immunity against the Bordetellae.
pubmed:affiliation	Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, 115 Henning Building, University Park, PA 16802, USA.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, N.I.H., Extramural