| pubmed-article:17590547 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17590547 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:17590547 | lifeskim:mentions | umls-concept:C0039062 | lld:lifeskim |
| pubmed-article:17590547 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:17590547 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:17590547 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
| pubmed-article:17590547 | lifeskim:mentions | umls-concept:C1948036 | lld:lifeskim |
| pubmed-article:17590547 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:17590547 | pubmed:dateCreated | 2007-7-30 | lld:pubmed |
| pubmed-article:17590547 | pubmed:abstractText | In the mouse brainstem cochlear nucleus, the auditory nerve to bushy cell synapse (endbulb of Held) is specialised for rapid, high-fidelity transmission. Development of this synapse is modulated by auditory nerve activity. Here we investigate the role of spontaneous auditory nerve activity in synaptic transmission using deafness (dn/dn) mutant mice that have abnormal hair cells and lack spontaneous auditory nerve activity. Evoked and miniature alpha amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor-mediated excitatory post-synaptic currents (eEPSCs, mEPSCs) were compared in deafness and normal mice before the age of hearing onset (postnatal day 7-11: P7-11) using variance-mean, miniature event and tetanic depression analyses. Amplitudes were significantly greater in deafness mice for eEPSCs (2.1-fold), mEPSCs (1.4-fold) and quantal amplitudes (1.5-fold). eEPSCs in deafness mice decayed more rapidly with increasing age, indicating an input-independent transition in post-synaptic AMPA receptor properties. A comparison of normal mice before and after the onset of hearing showed a change in synaptic parameters with an increase in eEPSC (1.7-fold), mEPSC (1.6-fold) and quantal amplitude (1.7-fold) after hearing onset while release probability remained constant (0.5). Overall, the results in deafness mice suggest that synaptic strength is altered in the absence of spontaneous auditory nerve activity. | lld:pubmed |
| pubmed-article:17590547 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17590547 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590547 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17590547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17590547 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17590547 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:17590547 | pubmed:issn | 0378-5955 | lld:pubmed |
| pubmed-article:17590547 | pubmed:author | pubmed-author:OleskevichSha... | lld:pubmed |
| pubmed-article:17590547 | pubmed:author | pubmed-author:McKaySarah... | lld:pubmed |
| pubmed-article:17590547 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17590547 | pubmed:volume | 230 | lld:pubmed |
| pubmed-article:17590547 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17590547 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17590547 | pubmed:pagination | 53-63 | lld:pubmed |
| pubmed-article:17590547 | pubmed:meshHeading | pubmed-meshheading:17590547... | lld:pubmed |
| pubmed-article:17590547 | pubmed:meshHeading | pubmed-meshheading:17590547... | lld:pubmed |
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| pubmed-article:17590547 | pubmed:meshHeading | pubmed-meshheading:17590547... | lld:pubmed |
| pubmed-article:17590547 | pubmed:meshHeading | pubmed-meshheading:17590547... | lld:pubmed |
| pubmed-article:17590547 | pubmed:meshHeading | pubmed-meshheading:17590547... | lld:pubmed |
| pubmed-article:17590547 | pubmed:meshHeading | pubmed-meshheading:17590547... | lld:pubmed |
| pubmed-article:17590547 | pubmed:meshHeading | pubmed-meshheading:17590547... | lld:pubmed |
| pubmed-article:17590547 | pubmed:meshHeading | pubmed-meshheading:17590547... | lld:pubmed |
| pubmed-article:17590547 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17590547 | pubmed:articleTitle | The role of spontaneous activity in development of the endbulb of Held synapse. | lld:pubmed |
| pubmed-article:17590547 | pubmed:affiliation | Neuroscience Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia. s.mckay@garvan.org.au | lld:pubmed |
| pubmed-article:17590547 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17590547 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:17590547 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:13409 | entrezgene:pubmed | pubmed-article:17590547 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17590547 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17590547 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17590547 | lld:pubmed |
