Source:http://linkedlifedata.com/resource/pubmed/id/17590547
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
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| pubmed:dateCreated |
2007-7-30
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| pubmed:abstractText |
In the mouse brainstem cochlear nucleus, the auditory nerve to bushy cell synapse (endbulb of Held) is specialised for rapid, high-fidelity transmission. Development of this synapse is modulated by auditory nerve activity. Here we investigate the role of spontaneous auditory nerve activity in synaptic transmission using deafness (dn/dn) mutant mice that have abnormal hair cells and lack spontaneous auditory nerve activity. Evoked and miniature alpha amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor-mediated excitatory post-synaptic currents (eEPSCs, mEPSCs) were compared in deafness and normal mice before the age of hearing onset (postnatal day 7-11: P7-11) using variance-mean, miniature event and tetanic depression analyses. Amplitudes were significantly greater in deafness mice for eEPSCs (2.1-fold), mEPSCs (1.4-fold) and quantal amplitudes (1.5-fold). eEPSCs in deafness mice decayed more rapidly with increasing age, indicating an input-independent transition in post-synaptic AMPA receptor properties. A comparison of normal mice before and after the onset of hearing showed a change in synaptic parameters with an increase in eEPSC (1.7-fold), mEPSC (1.6-fold) and quantal amplitude (1.7-fold) after hearing onset while release probability remained constant (0.5). Overall, the results in deafness mice suggest that synaptic strength is altered in the absence of spontaneous auditory nerve activity.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0378-5955
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
230
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
53-63
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| pubmed:meshHeading |
pubmed-meshheading:17590547-Aging,
pubmed-meshheading:17590547-Animals,
pubmed-meshheading:17590547-Auditory Pathways,
pubmed-meshheading:17590547-Cochlear Nerve,
pubmed-meshheading:17590547-Cochlear Nucleus,
pubmed-meshheading:17590547-Deafness,
pubmed-meshheading:17590547-Electric Stimulation,
pubmed-meshheading:17590547-Evoked Potentials,
pubmed-meshheading:17590547-Excitatory Postsynaptic Potentials,
pubmed-meshheading:17590547-Hearing,
pubmed-meshheading:17590547-Kinetics,
pubmed-meshheading:17590547-Mice,
pubmed-meshheading:17590547-Mice, Inbred CBA,
pubmed-meshheading:17590547-Mice, Neurologic Mutants,
pubmed-meshheading:17590547-Neural Conduction,
pubmed-meshheading:17590547-Receptors, AMPA,
pubmed-meshheading:17590547-Synapses,
pubmed-meshheading:17590547-Synaptic Transmission
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
The role of spontaneous activity in development of the endbulb of Held synapse.
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| pubmed:affiliation |
Neuroscience Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia. s.mckay@garvan.org.au
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| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|