Linked Life Data

17590393

Source:http://linkedlifedata.com/resource/pubmed/id/17590393

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7-8
pubmed:dateCreated
2007-10-22
pubmed:abstractText
The recent genome sequencing of several Streptococcus pyogenes serotype strains allowed the design of corresponding DNA microarrays and their usage for specific transcriptome analyses. In the present study, we employed transcriptomics together with functional tests to investigate the impact of the CiaH sensor gene of the CiaRH two-component regulator on gene expression and virulence traits of serotype M49 S. pyogenes strains CS101 and 591. In parallel, we studied the effects of the immunostimulatory substance Luivac on the serotype M49 S. pyogenes transcriptome and several biological features of serotype M1, M2, M3, M6, M18, and M49 S. pyogenes strains. Overall, the transcriptome analyses allowed a swift identification of differences in transcript abundance apparently associated with the observed strain-specific changes in matrix protein binding, eukaryotic cell interactions, or biofilm formation of the ciaH mutants and of wild-type strains exposed to a commercially available substance used for preventing upper respiratory tract infections.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1438-4221
pubmed:author
pubmed:issnType
Print
pubmed:volume
297
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
513-23
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Transcriptome analyses extend understanding of Streptococcus pyogenes regulatory mechanisms and behavior toward immunomodulatory substances.
pubmed:affiliation
Department of Medical Microbiology, Virology, and Hygiene, University Hospital Rostock, Schillingallee 70, D-18057 Rostock, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't