Linked Life Data

17587500

Source:http://linkedlifedata.com/resource/pubmed/id/17587500

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-7-9
pubmed:abstractText
T helper (Th) cells produce signature cytokine patterns, induced largely by intracellular versus extracellular pathogens that provide the cellular and molecular basis for counter regulatory expression of protective immunity during concurrent infections. The production of IL-12 and IFN-gamma, for example, resulting from exposure to many bacterial, viral, and protozoan pathogens is responsible for Th1-derived protective responses that also can inhibit development of Th2-cells expressing IL-4-dependent immunity to extracellular helminth parasites and vice versa. In a similar manner, concurrent helminth infection alters optimal vaccine-induced responses in humans and livestock; however, the consequences of this condition have not been adequately studied especially in the context of a challenge infection following vaccination. Demands for new and effective vaccines to control chronic and emerging diseases, and the need for rapid deployment of vaccines for bio security concerns requires a systematic evaluation of confounding factors that limit vaccine efficacy. One common albeit overlooked confounder is the presence of gastrointestinal nematode parasites in populations of humans and livestock targeted for vaccination. This is particularly important in areas of the world were helminth infections are prevalent, but the interplay between parasites and emerging diseases that can be transmitted worldwide make this a global issue. In addition, it is not clear if the epidemic in allergic disease in industrialized countries substitutes for geohelminth infection to interfere with effective vaccination regimens. This presentation will focus on recent vaccination studies in mice experimentally infected with Heligmosomoides polygyrus to model the condition of gastrointestinal parasite infestation in mammalian populations targeted for vaccination. In addition, a large animal vaccination and challenge model against Mycoplasma hyopneumonia in swine exposed to Ascaris suum will provide a specific example of the need for further work in this area, and for controlled field studies to assess the impact of other similar scenarios.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/AI031678, http://linkedlifedata.com/resource/pubmed/grant/AI047089, http://linkedlifedata.com/resource/pubmed/grant/AI049316, http://linkedlifedata.com/resource/pubmed/grant/AI066188, http://linkedlifedata.com/resource/pubmed/grant/DK055678, http://linkedlifedata.com/resource/pubmed/grant/DK058755, http://linkedlifedata.com/resource/pubmed/grant/R01 AI031678-06, http://linkedlifedata.com/resource/pubmed/grant/R01 AI031678-07, http://linkedlifedata.com/resource/pubmed/grant/R01 AI031678-08, http://linkedlifedata.com/resource/pubmed/grant/R01 AI031678-09, http://linkedlifedata.com/resource/pubmed/grant/R01 AI031678-10, http://linkedlifedata.com/resource/pubmed/grant/R01 AI031678-11, http://linkedlifedata.com/resource/pubmed/grant/R01 AI031678-12, http://linkedlifedata.com/resource/pubmed/grant/R01 AI031678-13, http://linkedlifedata.com/resource/pubmed/grant/R01 AI031678-14
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-10979919, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-11143198, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-11207651, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-12218148, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-1533656, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-15361233, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-15361238, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-15664955, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-15699158, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-15703613, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-16275759, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-16365440, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-16393954, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-16552043, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-16825660, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-16892038, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-17056555, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-17089770, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-17118349, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-17194810, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-2419430, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-8537675, http://linkedlifedata.com/resource/pubmed/commentcorrection/17587500-9521048
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0304-4017
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
148
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
14-20
pubmed:dateRevised
2011-4-28
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Infection with parasitic nematodes confounds vaccination efficacy.
pubmed:affiliation
Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD 20705-2350, USA. joe.urban@ars.usda.gov
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural