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pubmed:abstractText |
Protein motions play an essential role in catalysis and protein-ligand interactions, but are difficult to observe directly. A substantial fraction of protein motions involve hinge bending. For these proteins, the accurate identification of flexible hinges connecting rigid domains would provide significant insight into motion. Programs such as GNM and FIRST have made global flexibility predictions available at low computational cost, but are not designed specifically for finding hinge points.
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pubmed:affiliation |
Department of Physics, Yale University, Bass 432, New Haven, CT 06520, USA. samuel.flores@yale.edu <samuel.flores@yale.edu>
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