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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2007-7-10
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pubmed:abstractText |
The chemokine receptor CCR7 is a key organizer of the immune system. Gene targeting in mice revealed that Ccr7-deficient animals are severely impaired in the induction of central and peripheral tolerance. Due to these defects, Ccr7-deficient mice spontaneously develop multi-organ autoimmunity showing symptoms similar to those observed in humans suffering from connective tissue autoimmune diseases. However, it is unknown whether mutations of CCR7 are linked to autoimmunity in humans.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17587445-10520991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17587445-11018170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17587445-12480687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17587445-12732661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17587445-15302903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17587445-15308107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17587445-16473829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17587445-16533884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17587445-17082654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17587445-17304629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17587445-7138600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17587445-7378088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17587445-9531599
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2156
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17587445-Base Sequence,
pubmed-meshheading:17587445-DNA Primers,
pubmed-meshheading:17587445-Female,
pubmed-meshheading:17587445-Gene Frequency,
pubmed-meshheading:17587445-Genes, Reporter,
pubmed-meshheading:17587445-Genetic Predisposition to Disease,
pubmed-meshheading:17587445-Genetic Testing,
pubmed-meshheading:17587445-Germany,
pubmed-meshheading:17587445-Humans,
pubmed-meshheading:17587445-Luciferases,
pubmed-meshheading:17587445-Lupus Erythematosus, Systemic,
pubmed-meshheading:17587445-Male,
pubmed-meshheading:17587445-Molecular Sequence Data,
pubmed-meshheading:17587445-Polymorphism, Single Nucleotide,
pubmed-meshheading:17587445-Receptors, CCR7,
pubmed-meshheading:17587445-Scleroderma, Systemic,
pubmed-meshheading:17587445-Sequence Analysis, DNA,
pubmed-meshheading:17587445-Sjogren's Syndrome
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pubmed:year |
2007
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pubmed:articleTitle |
Genetic variants of chemokine receptor CCR7 in patients with systemic lupus erythematosus, Sjogren's syndrome and systemic sclerosis.
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pubmed:affiliation |
Institute of Immunology, Hannover Medical School, Hannover, Germany. danielkahlmann@yahoo.de <danielkahlmann@yahoo.de>
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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