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rdf:type |
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lifeskim:mentions |
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0021753,
umls-concept:C0022131,
umls-concept:C0030281,
umls-concept:C0031727,
umls-concept:C0040649,
umls-concept:C0169101,
umls-concept:C0441655,
umls-concept:C0795635,
umls-concept:C1337112
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pubmed:issue |
8
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pubmed:dateCreated |
2007-7-4
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pubmed:abstractText |
Inappropriate insulin secretion and biosynthesis are hallmarks of beta cell dysfunction and contribute to the progression from a prediabetic state to overt diabetes mellitus. During the prediabetic state, beta cells are exposed to elevated levels of proinflammatory cytokines. In the present study the effect of these cytokines and mitogen-activated protein kinase kinase kinase 1 (MEKK1), which is known to be activated by these cytokines, on human insulin gene (INS) transcription was investigated.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0012-186X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1678-87
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17583797-Animals,
pubmed-meshheading:17583797-Blotting, Western,
pubmed-meshheading:17583797-Cell Line,
pubmed-meshheading:17583797-Cell Line, Tumor,
pubmed-meshheading:17583797-Humans,
pubmed-meshheading:17583797-Insulin,
pubmed-meshheading:17583797-Insulin-Secreting Cells,
pubmed-meshheading:17583797-Interferon-gamma,
pubmed-meshheading:17583797-Interleukin-1beta,
pubmed-meshheading:17583797-Luciferases,
pubmed-meshheading:17583797-MAP Kinase Kinase Kinases,
pubmed-meshheading:17583797-Maf Transcription Factors,
pubmed-meshheading:17583797-Mice,
pubmed-meshheading:17583797-Mice, Transgenic,
pubmed-meshheading:17583797-Recombinant Fusion Proteins,
pubmed-meshheading:17583797-Response Elements,
pubmed-meshheading:17583797-Transcription, Genetic,
pubmed-meshheading:17583797-Transfection,
pubmed-meshheading:17583797-Tumor Necrosis Factor-alpha
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pubmed:year |
2007
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pubmed:articleTitle |
Inhibition of MafA transcriptional activity and human insulin gene transcription by interleukin-1beta and mitogen-activated protein kinase kinase kinase in pancreatic islet beta cells.
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pubmed:affiliation |
Department of Molecular Pharmacology, University of Göttingen, Robert-Koch-Strasse 40, 37099 Göttingen, Germany. eoetjen@med.uni-goettingen.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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