Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:17583784rdf:typepubmed:Citationlld:pubmed
pubmed-article:17583784lifeskim:mentionsumls-concept:C0035820lld:lifeskim
pubmed-article:17583784lifeskim:mentionsumls-concept:C0037868lld:lifeskim
pubmed-article:17583784lifeskim:mentionsumls-concept:C0013936lld:lifeskim
pubmed-article:17583784lifeskim:mentionsumls-concept:C0035668lld:lifeskim
pubmed-article:17583784pubmed:dateCreated2007-7-30lld:pubmed
pubmed-article:17583784pubmed:abstractTextRecently it has been demonstrated that, along with sperm, some of its RNA can be introduced into the oocyte during fertilization, which stays stable until the activation of the embryonic genome. Originally it was thought that RNA present in semen relates to contamination from somatic cells and/or immature sperm both containing substantially higher amounts of RNA than the fertilizing sperm. However, RNA is still found after stringent washing through density gradients resulting in a sperm fraction that is translational silenced and devoid of cytosolic rRNA and thus of potential RNA contamination-which is not transferable to the oocyte. Sperm only delivers a relatively small amount of paternal RNA (5-10 fg) into the fertilized oocyte when compared to the amount of maternal RNA (approximately 1 ng). Pooled human sperm contains about 5000 different mRNA sequences of which half are common between ejaculates. Besides mRNA sperm also contains small sperm RNA molecules that might interfere in gene expression (iRNA). In human sperm already more than 68 putative iRNAs have been identified and 15 of them may specifically inhibit genes that are only active during early embryonic development. The composition and quantity of sperm RNA is considered to be a valuable diagnostic tool for male fertility. However, only a subpopulation of the purified mature sperm fraction (with a yet unknown composition and quantity of RNA) will appropriately respond to capacitation media to become competent to fertilize the oocyte. In this review the origin and function of sperm borne RNA transferred into the oocyte is discussed along with their putative role in early embryogenesis, which still needs to be experimentally proven.lld:pubmed
pubmed-article:17583784pubmed:languageenglld:pubmed
pubmed-article:17583784pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17583784pubmed:citationSubsetIMlld:pubmed
pubmed-article:17583784pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17583784pubmed:statusMEDLINElld:pubmed
pubmed-article:17583784pubmed:monthSeplld:pubmed
pubmed-article:17583784pubmed:issn0093-691Xlld:pubmed
pubmed-article:17583784pubmed:authorpubmed-author:DielemanS JSJlld:pubmed
pubmed-article:17583784pubmed:authorpubmed-author:GadellaB MBMlld:pubmed
pubmed-article:17583784pubmed:authorpubmed-author:BoerkeAAlld:pubmed
pubmed-article:17583784pubmed:issnTypePrintlld:pubmed
pubmed-article:17583784pubmed:day1lld:pubmed
pubmed-article:17583784pubmed:volume68 Suppl 1lld:pubmed
pubmed-article:17583784pubmed:ownerNLMlld:pubmed
pubmed-article:17583784pubmed:authorsCompleteYlld:pubmed
pubmed-article:17583784pubmed:paginationS147-55lld:pubmed
pubmed-article:17583784pubmed:meshHeadingpubmed-meshheading:17583784...lld:pubmed
pubmed-article:17583784pubmed:meshHeadingpubmed-meshheading:17583784...lld:pubmed
pubmed-article:17583784pubmed:meshHeadingpubmed-meshheading:17583784...lld:pubmed
pubmed-article:17583784pubmed:meshHeadingpubmed-meshheading:17583784...lld:pubmed
pubmed-article:17583784pubmed:meshHeadingpubmed-meshheading:17583784...lld:pubmed
pubmed-article:17583784pubmed:meshHeadingpubmed-meshheading:17583784...lld:pubmed
pubmed-article:17583784pubmed:meshHeadingpubmed-meshheading:17583784...lld:pubmed
pubmed-article:17583784pubmed:meshHeadingpubmed-meshheading:17583784...lld:pubmed
pubmed-article:17583784pubmed:meshHeadingpubmed-meshheading:17583784...lld:pubmed
pubmed-article:17583784pubmed:meshHeadingpubmed-meshheading:17583784...lld:pubmed
pubmed-article:17583784pubmed:meshHeadingpubmed-meshheading:17583784...lld:pubmed
pubmed-article:17583784pubmed:year2007lld:pubmed
pubmed-article:17583784pubmed:articleTitleA possible role for sperm RNA in early embryo development.lld:pubmed
pubmed-article:17583784pubmed:affiliationDepartment of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.lld:pubmed
pubmed-article:17583784pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17583784pubmed:publicationTypeReviewlld:pubmed
pubmed-article:17583784pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17583784lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17583784lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17583784lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17583784lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17583784lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17583784lld:pubmed