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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1992-2-5
|
| pubmed:abstractText |
The synthesis and the acute toxicity and anticestodal activity of l-alkyl-4-[-(heterylamino)phenyl]-piperazines are presented. These compounds were found to be able to suppress the growth of larvocysts of Echinococcus multilocularis in cotton rats when injected intraperitoneally in a single dose of 0.25 g/kg, close to capacity of mebendazole. The tested compounds were also highly effective against the adult stage of Hymenolepis nana. Experimentally infected mice given an oral single dose of 0.2-0.5 g/kg of the drug were radically cured.
|
| pubmed:language |
rus
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0025-8326
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
55-7
|
| pubmed:dateRevised |
2009-10-21
|
| pubmed:meshHeading |
pubmed-meshheading:1758368-Animals,
pubmed-meshheading:1758368-Anticestodal Agents,
pubmed-meshheading:1758368-Drug Evaluation, Preclinical,
pubmed-meshheading:1758368-Echinococcosis,
pubmed-meshheading:1758368-Female,
pubmed-meshheading:1758368-Hymenolepiasis,
pubmed-meshheading:1758368-Male,
pubmed-meshheading:1758368-Mice,
pubmed-meshheading:1758368-Piperazines,
pubmed-meshheading:1758368-Sigmodontinae
|
| pubmed:articleTitle |
[The search for new antiparasitic agents. 8. The synthesis and study of the acute toxicity, anti-alveolar hydatid and antihymenolepiasis activity of 1-alkyl-4[4-(heterylamino)phenyl]piperazines].
|
| pubmed:publicationType |
Journal Article,
English Abstract
|