Source:http://linkedlifedata.com/resource/pubmed/id/17583543
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2007-10-31
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| pubmed:abstractText |
A high-performance liquid chromatographic method for the simultaneous determination of di(2-ethylhexyl)phthalate (DEHP) and its major metabolite mono(2-ethylhexyl)phthalate (MEHP) in seminal plasma was developed and validated. The method involves liquid-liquid extraction followed by isocratic reversed-phase chromatography with diode-array detection. The recovery, selectivity, linearity, precision and accuracy of the method were evaluated from the analysis of spiked seminal plasma samples. The effect of mobile-phase composition and pH on the retention of the target analytes was investigated. The limits of detection were 0.010 and 0.015 microg/mL, for DEHP and MEHP, respectively. This method was used to analyze real samples in support of clinical studies on these potential endocrine disruptors.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0269-3879
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright (c) 2007 John Wiley & Sons, Ltd.
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| pubmed:issnType |
Print
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| pubmed:volume |
21
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1166-71
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| pubmed:meshHeading |
pubmed-meshheading:17583543-Chemical Fractionation,
pubmed-meshheading:17583543-Chromatography, High Pressure Liquid,
pubmed-meshheading:17583543-Diethylhexyl Phthalate,
pubmed-meshheading:17583543-Electric Conductivity,
pubmed-meshheading:17583543-Environmental Exposure,
pubmed-meshheading:17583543-Environmental Monitoring,
pubmed-meshheading:17583543-Humans,
pubmed-meshheading:17583543-Male,
pubmed-meshheading:17583543-Molecular Structure,
pubmed-meshheading:17583543-Plasticizers,
pubmed-meshheading:17583543-Reference Standards,
pubmed-meshheading:17583543-Reproducibility of Results,
pubmed-meshheading:17583543-Semen,
pubmed-meshheading:17583543-Sensitivity and Specificity,
pubmed-meshheading:17583543-Specimen Handling,
pubmed-meshheading:17583543-Spectrometry, Mass, Electrospray Ionization
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| pubmed:year |
2007
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| pubmed:articleTitle |
HPLC with diode-array detection for the simultaneous determination of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate in seminal plasma.
|
| pubmed:affiliation |
Dipartimento di Chimica, Ingegneria Chimica e Materiali, Università di L'Aquila, Via Vetoio, 67010 Coppito, L'Aquila, Italy. mazzeo@univaq.it
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| pubmed:publicationType |
Journal Article,
Evaluation Studies
|