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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-5
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pubmed:dateCreated |
2007-8-13
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pubmed:abstractText |
17beta-Hydroxysteroid dehydrogenase (type V; HSD17B5) is a key enzyme involved in testosterone production in females. A single nucleotide polymorphism (SNP) in the promoter region of its gene was recently found to be associated with polycystic ovary syndrome (PCOS) and its related hyperandrogenaemia. Precocious pubarche (PP) is a clinical entity pointing to adrenal androgen excess from mid-childhood onward and is associated with ovarian androgen excess from puberty onward. It is therefore a strong risk factor for PCOS.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0960-0760
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
176-80
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17583494-17-Hydroxysteroid Dehydrogenases,
pubmed-meshheading:17583494-3-Hydroxysteroid Dehydrogenases,
pubmed-meshheading:17583494-Androgens,
pubmed-meshheading:17583494-Base Sequence,
pubmed-meshheading:17583494-DNA Primers,
pubmed-meshheading:17583494-Female,
pubmed-meshheading:17583494-Genotype,
pubmed-meshheading:17583494-Humans,
pubmed-meshheading:17583494-Hydroxyprostaglandin Dehydrogenases,
pubmed-meshheading:17583494-Linkage Disequilibrium,
pubmed-meshheading:17583494-Polymorphism, Single Nucleotide,
pubmed-meshheading:17583494-Puberty, Precocious
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pubmed:articleTitle |
Lack of association between common polymorphisms in the 17beta-hydroxysteroid dehydrogenase type V gene (HSD17B5) and precocious pubarche.
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pubmed:affiliation |
Department of Paediatrics, University of Cambridge, Cambridge CB2 2QQ, UK. cjp1002@cam.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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