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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2007-7-6
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pubmed:abstractText |
Polymorphisms of immune defence genes may act as disease modifiers and are studied by many researchers. A conclusive analysis of the impact of genetic variations typically requires a large number of sample specimens, and in retrospective studies this may include samples of reduced quality, e.g. formalin-fixed paraffin-embedded tissue specimens. Here we describe two new single-step methods for rapid and sensitive analysis of: 1. The G-129A myeloperoxidase (MPO) promoter polymorphism, which affects the amount of myeloperoxidase in neutrophils. 2. The Fc gamma receptor 2A (FCGR2A)-H/R131 polymorphism, which is critical to the binding of IgG2 immune complexes to phagocytes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1759
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
324
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
105-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17582430-Alanine,
pubmed-meshheading:17582430-Amino Acid Substitution,
pubmed-meshheading:17582430-Antibody Affinity,
pubmed-meshheading:17582430-Antigens, CD,
pubmed-meshheading:17582430-Arginine,
pubmed-meshheading:17582430-Cells, Cultured,
pubmed-meshheading:17582430-Glycine,
pubmed-meshheading:17582430-Histidine,
pubmed-meshheading:17582430-Humans,
pubmed-meshheading:17582430-Immunity, Innate,
pubmed-meshheading:17582430-Neutrophils,
pubmed-meshheading:17582430-Peroxidase,
pubmed-meshheading:17582430-Phagocytes,
pubmed-meshheading:17582430-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:17582430-Receptors, IgG,
pubmed-meshheading:17582430-Retrospective Studies,
pubmed-meshheading:17582430-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17582430-Tumor Cells, Cultured
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pubmed:year |
2007
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pubmed:articleTitle |
Rapid single-step methods for detection of two immune defence gene polymorphisms: the myeloperoxidase (MPO) G-129A and the Fc gamma receptor 2A (FCGR2A) H/R131.
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pubmed:affiliation |
Department of Haematology, Aarhus University Hospital, DK-8000 C, Denmark. rlg05im@as.aaa.dk
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pubmed:publicationType |
Journal Article
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