Linked Life Data

17581837

Source:http://linkedlifedata.com/resource/pubmed/id/17581837

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-8-31
pubmed:abstractText
Telomere shortening has been implicated in the aging process and various age-associated disorders, including renal disease. Moreover, oxidative stress has been identified as an initiator of accelerated telomere shortening. We have shown previously that maternal protein restriction during lactation leads to reduced renal telomere shortening, reduced albuminuria, and increased longevity in rats. Here we address the hypothesis that maternal protein restriction during lactation is nephroprotective and associated with increased expression of antioxidative enzymes and decreased age-dependent renal telomere shortening. Newborn rats were suckled by a dam fed either a control (20% protein) or low-protein (8% protein) diet. All animals were weaned onto standard chow. Offspring that had been suckled by protein-restricted mothers had reduced albuminuria, N-acetyl-glucosaminidase, and urinary aldosterone excretion. These animals also did not show significant age-dependent renal telomere shortening and hence had significantly longer telomeres at 12 mo of age. This lack of renal telomere shortening was associated with increased levels of the antioxidant enzymes manganese superoxide dismutase, glutathione peroxidase, and glutathione reductase. These findings suggest that beneficial effects of slow growth during lactation are associated with increased antioxidant capacity and prevention of age-dependent telomere shortening in the kidney.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0363-6119
pubmed:author
pubmed:issnType
Print
pubmed:volume
293
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R1259-66
pubmed:dateRevised
2008-2-26
pubmed:meshHeading
pubmed-meshheading:17581837-Acetylglucosaminidase, pubmed-meshheading:17581837-Albuminuria, pubmed-meshheading:17581837-Aldosterone, pubmed-meshheading:17581837-Animals, pubmed-meshheading:17581837-Antioxidants, pubmed-meshheading:17581837-Biological Markers, pubmed-meshheading:17581837-Birth Weight, pubmed-meshheading:17581837-Body Weight, pubmed-meshheading:17581837-Diet, pubmed-meshheading:17581837-Diet, Protein-Restricted, pubmed-meshheading:17581837-Female, pubmed-meshheading:17581837-Glutathione Peroxidase, pubmed-meshheading:17581837-Glutathione Reductase, pubmed-meshheading:17581837-Kidney, pubmed-meshheading:17581837-Kidney Cortex, pubmed-meshheading:17581837-Kidney Diseases, pubmed-meshheading:17581837-Kidney Function Tests, pubmed-meshheading:17581837-Lactation, pubmed-meshheading:17581837-Male, pubmed-meshheading:17581837-Pregnancy, pubmed-meshheading:17581837-Rats, pubmed-meshheading:17581837-Rats, Wistar, pubmed-meshheading:17581837-Superoxide Dismutase, pubmed-meshheading:17581837-Telomere
pubmed:year
2007
pubmed:articleTitle
Protein restriction in lactation confers nephroprotective effects in the male rat and is associated with increased antioxidant expression.
pubmed:affiliation
Department of Clinical Biochemistry, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge, UK. jane.adkins@ntlworld.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural