|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
15
|
|
pubmed:dateCreated |
2007-7-19
|
|
pubmed:abstractText |
Phosphonated carbocyclic 2'-oxa-3'-azanucleosides have been synthesized and tested for their antiretroviral activity. The obtained results have shown that some of the compounds were as powerful as azydothymidine in inhibiting the reverse transcriptase activity of the human retrovirus T-cell leukemia/lymphotropic virus type 1 and in protecting human peripheral blood mononuclear cells against human retrovirus T-cell leukemia/lymphotropic virus type 1 transmission in vitro. These data indicate that phosphonated carbocyclic 2'-oxa-3'-azanucleosides possess the necessary requirements to efficiently counteract infections caused by human retroviruses.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0022-2623
|
|
pubmed:author |
pubmed-author:BalestrieriEmanuelaE,
pubmed-author:BorrelloLuisaL,
pubmed-author:ChiacchioUgoU,
pubmed-author:IannazzoDanielaD,
pubmed-author:MacchiBeatriceB,
pubmed-author:MastinoAntonioA,
pubmed-author:PipernoAnnaA,
pubmed-author:RescifinaAntonioA,
pubmed-author:RomeoGiovanniG,
pubmed-author:RomeoRobertoR,
pubmed-author:SciortinoMaria TeresaMT
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
26
|
|
pubmed:volume |
50
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3747-50
|
|
pubmed:meshHeading |
pubmed-meshheading:17580846-Anti-Retroviral Agents,
pubmed-meshheading:17580846-Aza Compounds,
pubmed-meshheading:17580846-Human T-lymphotropic virus 1,
pubmed-meshheading:17580846-Humans,
pubmed-meshheading:17580846-Leukocytes, Mononuclear,
pubmed-meshheading:17580846-Phosphonic Acids,
pubmed-meshheading:17580846-Purine Nucleosides,
pubmed-meshheading:17580846-Pyrimidine Nucleosides,
pubmed-meshheading:17580846-Reverse Transcriptase Inhibitors,
pubmed-meshheading:17580846-Structure-Activity Relationship
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Phosphonated carbocyclic 2'-oxa-3'-azanucleosides as new antiretroviral agents.
|
|
pubmed:affiliation |
Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, Catania 95125, Italy.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
