Source:http://linkedlifedata.com/resource/pubmed/id/17579196
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2007-9-7
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pubmed:abstractText |
Hypospadias is a common inborn error of the male genitalia of complex, and still elusive, etiology. The presence of active estrogen receptors (ESRs) in the developing male urethra, predominantly the ESR2, has suggested a role of estrogens in the otherwise androgen-dependent male genital differetiation. Moreover, imbalances between these two steroid hormones have been suggested to disturb the external genital development. This has been supported by the association between longer (CA)n variants in the ESR2 gene with lower androgen levels as well as with hypospadias.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-972X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3712-8
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pubmed:meshHeading |
pubmed-meshheading:17579196-Case-Control Studies,
pubmed-meshheading:17579196-Child,
pubmed-meshheading:17579196-Cohort Studies,
pubmed-meshheading:17579196-Estrogen Receptor beta,
pubmed-meshheading:17579196-Genetic Predisposition to Disease,
pubmed-meshheading:17579196-Genotype,
pubmed-meshheading:17579196-Humans,
pubmed-meshheading:17579196-Hypospadias,
pubmed-meshheading:17579196-Linkage Disequilibrium,
pubmed-meshheading:17579196-Male,
pubmed-meshheading:17579196-Microsatellite Repeats,
pubmed-meshheading:17579196-Polymorphism, Single Nucleotide,
pubmed-meshheading:17579196-Risk Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Risk factors for hypospadias in the estrogen receptor 2 gene.
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pubmed:affiliation |
Department of Molecular Medicine and Surgery, Building CMM 00, Karolinska University Hospital, Solna, SE 171 76 Stockholm, Sweden. Ana.Beleza@ki.se
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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