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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-6-20
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pubmed:abstractText |
Differentiation of CD4+CD8+ double-positive thymocytes into CD8+ single-positive (SP) thymocytes is regulated by TCR and cytokine receptor signals. Previously, we have shown that expression of stabilized beta-catenin, the major transcriptional cofactor of T cell factor, results in increase in both CD4SP and CD8SP thymocytes with a preferential effect on CD8SP thymocytes. In this report, using mice expressing stabilized beta-catenin and mice with T cell specific deletion of beta-catenin, we show that beta-catenin expression augments IL-7Ralpha-chain expression and down-regulates suppressor of cytokine signaling-1 expression in thymocytes undergoing positive selection. Consequently, beta-catenin expression augments IL-7R signaling in thymocytes during positive selection and promotes the development of CD8SP thymocytes.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-10209158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-10490100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-10933395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-11526403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-12033737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-12591905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-12705851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-12957410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-14608382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-14634095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-14645157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-14718516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-15135629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-15229472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-15630426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-15890681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-16390939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-7546378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-7612239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-7697543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-7699333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-7964471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-9118222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-9215626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-9566975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17579030-9845363
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-7,
http://linkedlifedata.com/resource/pubmed/chemical/STAT5 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Socs1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Stat5a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Suppressor of Cytokine Signaling...,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
179
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
126-31
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17579030-Adjuvants, Immunologic,
pubmed-meshheading:17579030-Animals,
pubmed-meshheading:17579030-Antigens, CD4,
pubmed-meshheading:17579030-Antigens, CD8,
pubmed-meshheading:17579030-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17579030-Cell Differentiation,
pubmed-meshheading:17579030-Cells, Cultured,
pubmed-meshheading:17579030-Down-Regulation,
pubmed-meshheading:17579030-Lymphocyte Count,
pubmed-meshheading:17579030-Mice,
pubmed-meshheading:17579030-Mice, Knockout,
pubmed-meshheading:17579030-Mice, Transgenic,
pubmed-meshheading:17579030-Receptors, Interleukin-7,
pubmed-meshheading:17579030-STAT5 Transcription Factor,
pubmed-meshheading:17579030-Signal Transduction,
pubmed-meshheading:17579030-Suppressor of Cytokine Signaling Proteins,
pubmed-meshheading:17579030-T-Lymphocyte Subsets,
pubmed-meshheading:17579030-Thymus Gland,
pubmed-meshheading:17579030-beta Catenin
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pubmed:year |
2007
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pubmed:articleTitle |
Beta-catenin expression enhances IL-7 receptor signaling in thymocytes during positive selection.
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pubmed:affiliation |
Lymphocyte Development Unit, Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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