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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-6-19
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pubmed:abstractText |
Limited clinical trials have validated the hypothesis of controlling graft-versus-host disease (GVHD) arising from stem cell transplant utilizing suicidal T-lymphocytes that have been transduced to express the HSV-TK gene. However, clinical utility has been limited by diminished T-cell function arising from the production process. To evaluate strategies for harnessing the graft-versus-leukemia (GVL) effect while improving the safety and function of suicidal lymphocytes, we have developed techniques to produce fully functional, retrovirally transduced, HSV-TK-positive murine T cells (TK+TC).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0301-472X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
842-53
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17577932-Animals,
pubmed-meshheading:17577932-Bone Marrow Transplantation,
pubmed-meshheading:17577932-Cytokines,
pubmed-meshheading:17577932-Disease Models, Animal,
pubmed-meshheading:17577932-Dose-Response Relationship, Immunologic,
pubmed-meshheading:17577932-Female,
pubmed-meshheading:17577932-Ganciclovir,
pubmed-meshheading:17577932-Graft vs Host Disease,
pubmed-meshheading:17577932-Injections, Intraperitoneal,
pubmed-meshheading:17577932-Injections, Subcutaneous,
pubmed-meshheading:17577932-Leukemia,
pubmed-meshheading:17577932-Male,
pubmed-meshheading:17577932-Mice,
pubmed-meshheading:17577932-Mice, Inbred AKR,
pubmed-meshheading:17577932-Phenotype,
pubmed-meshheading:17577932-Retroviridae,
pubmed-meshheading:17577932-Survival Rate,
pubmed-meshheading:17577932-T-Lymphocytes,
pubmed-meshheading:17577932-Transduction, Genetic,
pubmed-meshheading:17577932-Transplantation, Homologous
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pubmed:year |
2007
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pubmed:articleTitle |
Control of graft-versus-host disease with maintenance of the graft-versus-leukemia effect in a murine allogeneic transplant model using retrovirally transduced murine suicidal lymphocytes.
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pubmed:affiliation |
Department of Blood and Marrow Transplantation, Unit 448, M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030-4009, USA. skornbla@mdanderson.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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