|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2007-7-3
|
|
pubmed:abstractText |
QT prolongation is an important risk factor for sudden cardiac death. About 35% of QT-interval variation is heritable. In a recent genome-wide association study, a common variant (rs10494366) in the nitric oxide synthase 1 adaptor protein (NOS1AP) gene was found to be associated with QT-interval variation. We tested for association of 2 NOS1AP variants with QT duration and sudden cardiac death.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1524-4539
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
3
|
|
pubmed:volume |
116
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
10-6
|
|
pubmed:dateRevised |
2008-1-9
|
|
pubmed:meshHeading |
pubmed-meshheading:17576865-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:17576865-Aged,
pubmed-meshheading:17576865-Aged, 80 and over,
pubmed-meshheading:17576865-Alleles,
pubmed-meshheading:17576865-Cardiovascular Agents,
pubmed-meshheading:17576865-Cohort Studies,
pubmed-meshheading:17576865-Death, Sudden, Cardiac,
pubmed-meshheading:17576865-Electrocardiography,
pubmed-meshheading:17576865-Female,
pubmed-meshheading:17576865-Follow-Up Studies,
pubmed-meshheading:17576865-Genotype,
pubmed-meshheading:17576865-Haplotypes,
pubmed-meshheading:17576865-Humans,
pubmed-meshheading:17576865-Long QT Syndrome,
pubmed-meshheading:17576865-Male,
pubmed-meshheading:17576865-Middle Aged,
pubmed-meshheading:17576865-Netherlands,
pubmed-meshheading:17576865-Phenotype,
pubmed-meshheading:17576865-Polymorphism, Single Nucleotide,
pubmed-meshheading:17576865-Proportional Hazards Models,
pubmed-meshheading:17576865-Prospective Studies,
pubmed-meshheading:17576865-Risk Factors,
pubmed-meshheading:17576865-Suburban Population
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study.
|
|
pubmed:affiliation |
Department of Epidemiology and Biostatistics, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
