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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2007-10-2
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pubmed:abstractText |
We showed that RGS18, a myeloid lineage-specific RGS protein that is inhibited after activation of the RANK/RANKL system, is a negative regulator of osteoclastogenesis. RGS18 acts through an external acidosis-sensing osteoclastogenic mechanism through the OGR1/NFAT pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acids,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/NFATC Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Subunits,
http://linkedlifedata.com/resource/pubmed/chemical/RANK Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Rgs18 protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0884-0431
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1612-20
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pubmed:meshHeading |
pubmed-meshheading:17576169-Acids,
pubmed-meshheading:17576169-Animals,
pubmed-meshheading:17576169-Bone and Bones,
pubmed-meshheading:17576169-Cell Nucleus,
pubmed-meshheading:17576169-Cells, Cultured,
pubmed-meshheading:17576169-GTP-Binding Proteins,
pubmed-meshheading:17576169-Gene Expression Regulation,
pubmed-meshheading:17576169-Hydrogen-Ion Concentration,
pubmed-meshheading:17576169-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:17576169-Mice,
pubmed-meshheading:17576169-NFATC Transcription Factors,
pubmed-meshheading:17576169-Osteoclasts,
pubmed-meshheading:17576169-Osteogenesis,
pubmed-meshheading:17576169-Protein Subunits,
pubmed-meshheading:17576169-RANK Ligand,
pubmed-meshheading:17576169-RNA, Small Interfering,
pubmed-meshheading:17576169-Receptors, G-Protein-Coupled,
pubmed-meshheading:17576169-Signal Transduction
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pubmed:year |
2007
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pubmed:articleTitle |
RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway.
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pubmed:affiliation |
Department of Clinical Research, National Hospital Organization, Osaka, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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