|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0016055,
umls-concept:C0031268,
umls-concept:C0032743,
umls-concept:C0086418,
umls-concept:C1335676,
umls-concept:C1514562,
umls-concept:C1519670,
umls-concept:C1566673,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
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|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2007-7-3
|
|
pubmed:abstractText |
The aim of this study was to image the extra domain B (ED-B) of fibronectin, an angiogenesis-related target, in solid tumors using small-animal PET. Toward this aim, an ED-B fibronectin-binding human antibody derivative (L19-SIP) was labeled with (76)Br via an enzymatic approach. Biodistribution and imaging studies were performed in human teratoma-bearing mice for up to 48 h after injection.
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|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0161-5505
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
48
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1172-9
|
|
pubmed:dateRevised |
2010-10-6
|
|
pubmed:meshHeading |
pubmed-meshheading:17574989-Animals,
pubmed-meshheading:17574989-Antibodies,
pubmed-meshheading:17574989-Bromine Radioisotopes,
pubmed-meshheading:17574989-Cell Line, Tumor,
pubmed-meshheading:17574989-Female,
pubmed-meshheading:17574989-Fibronectins,
pubmed-meshheading:17574989-Humans,
pubmed-meshheading:17574989-Mice,
pubmed-meshheading:17574989-Neoplasm Transplantation,
pubmed-meshheading:17574989-Neoplasms, Experimental,
pubmed-meshheading:17574989-Neovascularization, Pathologic,
pubmed-meshheading:17574989-Positron-Emission Tomography,
pubmed-meshheading:17574989-Radiopharmaceuticals,
pubmed-meshheading:17574989-Recombinant Proteins,
pubmed-meshheading:17574989-Tissue Distribution,
pubmed-meshheading:17574989-Transplantation, Heterologous
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Small-animal PET of tumor angiogenesis using a (76)Br-labeled human recombinant antibody fragment to the ED-B domain of fibronectin.
|
|
pubmed:affiliation |
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
