Source:http://linkedlifedata.com/resource/pubmed/id/17574959
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2007-6-18
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| pubmed:abstractText |
A retrospective cytogenetic study of acute myeloid leukemias (AML) and myelodysplastic syndromes (MDS) was conducted by the Groupe Francophone de Cytogénétique Hématologique (GFCH) to evaluate the structural abnormalities of chromosome 5 associated with other chromosomal abnormalities, in particular of chromosome 7, in these pathologies. In all, 110 cases of AML/MDS were recruited based on the presence of chromosome 5 abnormalities under conventional cytogenetics and supplemented by a systematic fluorescence in situ hybridization study of chromosomes 5 and 7. The abnormalities of the long arm of chromosome 5 (5q) were deletions of various sizes and sometimes cryptic. The 5q abnormalities were associated with translocations in 54% of cases and were simple deletions in 46%. In 68% of cases, 5q deletions were associated with chromosome 7 abnormalities, and 90% of these presented a complex karyotype. Of the 110 patients, 28 had a hematopoietic disorder secondary to chemotherapy, radiotherapy, or both. Among 82 patients with de novo AML/MDS, 63 were older than 60 years. Chromosomal abnormalities often associated hypodiploidy and chromosome 5 and 7 abnormalities in complex karyotypes, features resembling those of secondary hemopathies. Systematic investigation of the exposure to mutagens and oncogenes is thus essential to specify the factors potentially involved in MDS/AML with 5q abnormalities.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0165-4608
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| pubmed:author |
pubmed-author:BarilMM,
pubmed-author:BergerRR,
pubmed-author:BrizardFF,
pubmed-author:Cornillet-LefebvrePP,
pubmed-author:DastugueNN,
pubmed-author:DesanglesFF,
pubmed-author:EclacheVV,
pubmed-author:Groupe Francophone de Cytogénétique Hématologique,
pubmed-author:HéliasCC,
pubmed-author:HerryAA,
pubmed-author:Lafage-PochitaloffMM,
pubmed-author:LespinasseJJ,
pubmed-author:LessardMM,
pubmed-author:LuquetII,
pubmed-author:MichauxLL,
pubmed-author:MozziconacciM-JMJ,
pubmed-author:MugneretFF,
pubmed-author:PerrotCC,
pubmed-author:PerrussonNN,
pubmed-author:StruskiSS,
pubmed-author:TervoAA,
pubmed-author:UettwillerFF,
pubmed-author:Van den AkkerJJ,
pubmed-author:Verellen-DumoulinCC
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| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
176
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1-21
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| pubmed:meshHeading |
pubmed-meshheading:17574959-Acute Disease,
pubmed-meshheading:17574959-Adolescent,
pubmed-meshheading:17574959-Adult,
pubmed-meshheading:17574959-Aged,
pubmed-meshheading:17574959-Aged, 80 and over,
pubmed-meshheading:17574959-Antineoplastic Agents,
pubmed-meshheading:17574959-Chromosome Aberrations,
pubmed-meshheading:17574959-Chromosome Deletion,
pubmed-meshheading:17574959-Chromosomes, Human, Pair 5,
pubmed-meshheading:17574959-Chromosomes, Human, Pair 7,
pubmed-meshheading:17574959-Female,
pubmed-meshheading:17574959-Humans,
pubmed-meshheading:17574959-In Situ Hybridization, Fluorescence,
pubmed-meshheading:17574959-Leukemia, Myeloid,
pubmed-meshheading:17574959-Male,
pubmed-meshheading:17574959-Middle Aged,
pubmed-meshheading:17574959-Myelodysplastic Syndromes,
pubmed-meshheading:17574959-Neoplasms, Radiation-Induced,
pubmed-meshheading:17574959-Translocation, Genetic
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| pubmed:year |
2007
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| pubmed:articleTitle |
Fluorescence in situ hybridization analysis of 110 hematopoietic disorders with chromosome 5 abnormalities: do de novo and therapy-related myelodysplastic syndrome-acute myeloid leukemia actually differ?
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| pubmed:affiliation |
Laboratory of Hematology, Hautepierre Hospital, Avenue Molière, Strasbourg 67098, France. Michel.lessard@chru-strasbourg.fr
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| pubmed:publicationType |
Journal Article
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