Linked Life Data

17574707

Source:http://linkedlifedata.com/resource/pubmed/id/17574707

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2008-10-22
pubmed:abstractText
Vascular endothelial growth factor (VEGF) gene polymorphisms have been associated with an increased risk of developing a wide variety of disorders from diabetes to neurodegenerative diseases suggesting functions not confined to its vascular effects originally described. Based on the VEGF protective roles undisclosed in pathological conditions, we evaluate whether VEGF variability might be a determinant also for longevity. Four polymorphisms (-2578C/A, -1190G/A, -1154G/A and -634G/C) within the VEGF gene promoter region in 490 unrelated Italian healthy subjects have been analysed. Significant changes of allele, genotype (-2578/AA versus -2578/CC: OR=2.08, p=0.007; -1190/AA versus -1190/GG: OR=2.01, p=0.011) and haplotype (AAGG: 10.4% versus 14.9%, p=0.03) frequency distributions were observed between young/elderly (25-84 years old) and long-lived (85-99 years old) subjects. These results suggest that VEGF gene variability can be inserted among the genetic factors influencing the lifespan.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1558-1497
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1917-22
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Role of VEGF gene variability in longevity: a lesson from the Italian population.
pubmed:affiliation
Department of Neurological Sciences, Dino Ferrari Centre, University of Milan, IRCCS Foundation Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Padiglione Ponti, Milano, Italy. roberto.delbo@unimi.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't