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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2007-7-30
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pubmed:databankReference |
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pubmed:abstractText |
This manuscript describes the design and synthesis of a series of pyrrole-based inhibitors of HMG-CoA reductase for the treatment of hypercholesterolemia. Analogs were optimized using structure-based design and physical property considerations resulting in the identification of 44, a hepatoselective HMG-CoA reductase inhibitor with excellent acute and chronic efficacy in a pre-clinical animal models.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:AskewValerieV,
pubmed-author:AuerbachBruceB,
pubmed-author:BainbridgeGraemeG,
pubmed-author:BrattonLarry DLD,
pubmed-author:CaspersNicoleN,
pubmed-author:ChenHuifenH,
pubmed-author:ChengXue-MinXM,
pubmed-author:ChoiChulhoC,
pubmed-author:DillonLisaL,
pubmed-author:EberstadtMatthiasM,
pubmed-author:ErasgaNoeN,
pubmed-author:HanselmanJeffrey CJC,
pubmed-author:HarrisMelissa SMS,
pubmed-author:LarsenScott DSD,
pubmed-author:LeeChitaseC,
pubmed-author:LinZhiwuZ,
pubmed-author:LuGinaG,
pubmed-author:MertzThomasT,
pubmed-author:MillerSteven RSR,
pubmed-author:OlsenKarlK,
pubmed-author:PavlovskyAlexanderA,
pubmed-author:PfefferkornJeffrey AJA,
pubmed-author:PoelToni-JoTJ,
pubmed-author:RobertsonAndrewA,
pubmed-author:SekerkeCatherineC,
pubmed-author:SongYuntaoY,
pubmed-author:SorensonRoderick JRJ,
pubmed-author:SunKuai-LinKL,
pubmed-author:TrivediBharat KBK,
pubmed-author:UnangstPaul CPC
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4538-44
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pubmed:meshHeading |
pubmed-meshheading:17574412-Animals,
pubmed-meshheading:17574412-Cricetinae,
pubmed-meshheading:17574412-Dose-Response Relationship, Drug,
pubmed-meshheading:17574412-Drug Design,
pubmed-meshheading:17574412-Fluorobenzenes,
pubmed-meshheading:17574412-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:17574412-Hyperlipidemias,
pubmed-meshheading:17574412-Liver,
pubmed-meshheading:17574412-Models, Molecular,
pubmed-meshheading:17574412-Molecular Structure,
pubmed-meshheading:17574412-Pyrimidines,
pubmed-meshheading:17574412-Pyrroles,
pubmed-meshheading:17574412-Structure-Activity Relationship,
pubmed-meshheading:17574412-Sulfonamides
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pubmed:year |
2007
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pubmed:articleTitle |
Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.
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pubmed:affiliation |
Pfizer Global Research & Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. jeffrey.a.pfefferkorn@pfizer.com
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pubmed:publicationType |
Journal Article
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