Source:http://linkedlifedata.com/resource/pubmed/id/17573336
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2007-8-10
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| pubmed:abstractText |
Clustering of long-term rates of change in metabolic syndrome variables (body mass index, homeostasis model assessment of insulin resistance, ratio of triglycerides to high-density lipoprotein cholesterol, and mean arterial pressure) from childhood to adulthood was evaluated longitudinally (1982-2003) in a cohort of 389 Blacks and 631 Whites who were examined 3-6 times both as children (ages 4-17 years) and as adults (ages 18-38 years) over an average of 16 years (3,874 observations). The incremental area under the growth curve was used as a measure of long-term rates of change in risk variables since childhood. Intraclass correlations, a measure of the degree of clustering, among the four variables were significant (p < 0.001) for childhood, adulthood, and incremental area values and were higher in adulthood than in childhood. Blacks showed a higher degree of clustering of long-term rates of change in risk variables than did Whites. Adjustment for body mass index reduced the degree of clustering by approximately 50%. These results show that metabolic syndrome variables coexist in terms not only of their levels in childhood and adulthood but also of long-term rates of change. Obesity is of critical importance in the development of metabolic syndrome, and its prevention beginning in childhood needs to be addressed.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0002-9262
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
166
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
527-33
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| pubmed:dateRevised |
2007-12-3
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| pubmed:meshHeading |
pubmed-meshheading:17573336-Adolescent,
pubmed-meshheading:17573336-Adult,
pubmed-meshheading:17573336-African Americans,
pubmed-meshheading:17573336-Aging,
pubmed-meshheading:17573336-Area Under Curve,
pubmed-meshheading:17573336-Blood Pressure,
pubmed-meshheading:17573336-Body Mass Index,
pubmed-meshheading:17573336-Cardiovascular Diseases,
pubmed-meshheading:17573336-Child,
pubmed-meshheading:17573336-Child, Preschool,
pubmed-meshheading:17573336-Cholesterol, HDL,
pubmed-meshheading:17573336-Cluster Analysis,
pubmed-meshheading:17573336-Cross-Sectional Studies,
pubmed-meshheading:17573336-European Continental Ancestry Group,
pubmed-meshheading:17573336-Female,
pubmed-meshheading:17573336-Humans,
pubmed-meshheading:17573336-Insulin Resistance,
pubmed-meshheading:17573336-Longitudinal Studies,
pubmed-meshheading:17573336-Louisiana,
pubmed-meshheading:17573336-Male,
pubmed-meshheading:17573336-Metabolic Syndrome X,
pubmed-meshheading:17573336-Risk Factors,
pubmed-meshheading:17573336-Triglycerides
|
| pubmed:year |
2007
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| pubmed:articleTitle |
Clustering of long-term trends in metabolic syndrome variables from childhood to adulthood in Blacks and Whites: the Bogalusa Heart Study.
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| pubmed:affiliation |
Tulane Center for Cardiovascular Health, Tulane University, New Orleans, LA 70112, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|