Source:http://linkedlifedata.com/resource/pubmed/id/17571947
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2007-6-18
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| pubmed:abstractText |
Dietary deficiency of folate and other micronutrients involved in the one-carbon metabolism (i.e., vitamins B2, B6, B12, and methionine) have been related to several diseases, including cancers, but results on non-Hodgkin lymphoma (NHL) are controversial. A hospital-based case-control study was conducted in Italy, in 1999-2002. Cases were 190 incident, histologically confirmed NHL aged 18-84 years. Controls were 484 subjects admitted to hospitals for acute, non-neoplastic diseases supposed to be unrelated to alcohol consumption or to diet modification. Dietary habits, including alcohol drinking, were assessed by a validated food-frequency questionnaire. Nutrient intakes were computed using the Italian food composition database. Odds ratios (ORs) and corresponding 95% confidence intervals for tertiles of nutrients' intake were computed using the energy-adjusted residual models. No significant association emerged between NHL risk and intakes of folate (OR=0.9), vitamin B2 (OR=0.9), vitamin B6 (OR=0.8), and methionine (OR=0.7). However, a significant inverse association was observed for all the nutrients examined among abstainers and former drinkers, whereas no relations between one-carbon nutrients and NHL risk emerged among current alcohol drinkers. Our findings support the possibility of an antagonist effect of alcohol on the one-carbon metabolism in NHL etiology. However, the lack of an overall effect for one-carbon nutrients and the small sample size suggested caution in interpreting our results.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0163-5581
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
57
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
146-50
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| pubmed:meshHeading |
pubmed-meshheading:17571947-Adolescent,
pubmed-meshheading:17571947-Adult,
pubmed-meshheading:17571947-Aged,
pubmed-meshheading:17571947-Aged, 80 and over,
pubmed-meshheading:17571947-Alcohol Drinking,
pubmed-meshheading:17571947-Carbon,
pubmed-meshheading:17571947-Case-Control Studies,
pubmed-meshheading:17571947-Confidence Intervals,
pubmed-meshheading:17571947-Female,
pubmed-meshheading:17571947-Folic Acid,
pubmed-meshheading:17571947-Folic Acid Deficiency,
pubmed-meshheading:17571947-Humans,
pubmed-meshheading:17571947-Italy,
pubmed-meshheading:17571947-Lymphoma, Non-Hodgkin,
pubmed-meshheading:17571947-Male,
pubmed-meshheading:17571947-Middle Aged,
pubmed-meshheading:17571947-Odds Ratio,
pubmed-meshheading:17571947-Questionnaires,
pubmed-meshheading:17571947-Risk Factors,
pubmed-meshheading:17571947-Vitamin B Complex
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Dietary folate, alcohol consumption, and risk of non-Hodgkin lymphoma.
|
| pubmed:affiliation |
Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano, Italy. polesel@cro.it
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|