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pubmed:abstractText |
TIM-1, a member of the T cell immunoglobulin and mucin domain (TIM) gene family was implicated as an asthma susceptibility gene in previous studies. TIM-1 is selectively expressed on activated CD4+ T cells and its expression is sustained preferentially on T helper type 2 (Th2) cells, which suggests that TIM-1 is associated with T cell differentiation and the development of Th2-biased immune response.
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pubmed:affiliation |
Key Laboratory of Experimental Teratology, Ministry of Education, China, Institute of Medical Genetics, School of Medicine, Shandong University, Jinan, PR China.
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