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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5835
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pubmed:dateCreated |
2007-7-13
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pubmed:abstractText |
The cytokine transforming growth factor-beta (TGF-beta) converts naïve T cells into regulatory T (Treg) cells that prevent autoimmunity. However, in the presence of interleukin-6 (IL-6), TGF-beta has also been found to promote the differentiation of naïve T lymphocytes into proinflammatory IL-17 cytokine-producing T helper 17 (T(H)17) cells, which promote autoimmunity and inflammation. This raises the question of how TGF-beta can generate such distinct outcomes. We identified the vitamin A metabolite retinoic acid as a key regulator of TGF-beta-dependent immune responses, capable of inhibiting the IL-6-driven induction of proinflammatory T(H)17 cells and promoting anti-inflammatory Treg cell differentiation. These findings indicate that a common metabolite can regulate the balance between pro- and anti-inflammatory immunity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
13
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pubmed:volume |
317
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
256-60
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17569825-Animals,
pubmed-meshheading:17569825-Cell Differentiation,
pubmed-meshheading:17569825-Cells, Cultured,
pubmed-meshheading:17569825-Colitis,
pubmed-meshheading:17569825-Dendritic Cells,
pubmed-meshheading:17569825-Dibenzazepines,
pubmed-meshheading:17569825-Forkhead Transcription Factors,
pubmed-meshheading:17569825-Interleukin-17,
pubmed-meshheading:17569825-Interleukin-2,
pubmed-meshheading:17569825-Interleukin-6,
pubmed-meshheading:17569825-Intestinal Mucosa,
pubmed-meshheading:17569825-Listeriosis,
pubmed-meshheading:17569825-Lymphocyte Activation,
pubmed-meshheading:17569825-Mice,
pubmed-meshheading:17569825-Mice, Inbred C57BL,
pubmed-meshheading:17569825-Mice, Transgenic,
pubmed-meshheading:17569825-Spleen,
pubmed-meshheading:17569825-T-Lymphocyte Subsets,
pubmed-meshheading:17569825-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:17569825-T-Lymphocytes, Regulatory,
pubmed-meshheading:17569825-Transforming Growth Factor beta,
pubmed-meshheading:17569825-Tretinoin
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pubmed:year |
2007
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pubmed:articleTitle |
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid.
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pubmed:affiliation |
La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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