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pubmed:abstractText |
Disruption of the permeability barrier stimulates a repair response that leads to the restoration of barrier function. Previous studies demonstrated that changes in ions, particularly calcium, and cytokines are positive signals, whereas serine protease activation of proteinase-activated receptor 2 is a negative signal regulating barrier recovery. Ikeyama and colleagues provide data that the nitric oxide signaling pathway also regulates barrier homeostasis.
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pubmed:affiliation |
Department of Medicine, University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, California 94121, USA. kenneth.feingold@ucsf.edu
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