Linked Life Data

17567475

Source:http://linkedlifedata.com/resource/pubmed/id/17567475

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-6-14
pubmed:abstractText
Although non-alcoholic steatohepatitis (NASH) has become a common disease worldwide, its pathogenesis remains unclear. Establishment of a proper animal model is a prerequisite for analyzing the molecular mechanism of this disease. A NASH model has been developed using rabbits fed a high-fat diet. These rabbits developed prominent fatty changes in hepatocytes. Hepatic fibrosis was seen around hepatocytes and the portal vein area. Apoptotic hepatocytes, which were rare in the intact liver, appeared in the liver of high-fat diet-fed rabbits. It is speculated that Kupffer cells/macrophages may play an important role in triggering the generation of oxidative stress in this model. Thus, this rabbit model is proposed for use in the molecular analysis of human NASH.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0815-9319
pubmed:author
pubmed:issnType
Print
pubmed:volume
22 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S85-6
pubmed:dateRevised
2010-6-9
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Role of oxidative stress and Kupffer cells in hepatic fibrosis.
pubmed:affiliation
Department of Hepatology, Graduate School of Medicine, Osaka City University, Abeno, Osaka, Japan. kawadanori@med.osaka-cu.ac.jp
pubmed:publicationType
Journal Article