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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-6-14
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pubmed:abstractText |
Thrombin is a major physiological platelet agonist that activates a number of cell functions including aggregation. Platelet stimulation with thrombin has been shown to result in the development of apoptotic events, including activation of caspases-3 and -9, cytochrome c release and phosphatidylserine (PS) exposure; however, the mechanism underlying the activation of apoptosis remains unclear.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CASP9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Catalase,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochromes c,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorescent Dyes,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylserines,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Thrombin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1538-7933
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1283-91
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pubmed:meshHeading |
pubmed-meshheading:17567446-Apoptosis,
pubmed-meshheading:17567446-Blood Platelets,
pubmed-meshheading:17567446-Caspase 3,
pubmed-meshheading:17567446-Caspase 9,
pubmed-meshheading:17567446-Catalase,
pubmed-meshheading:17567446-Cytochromes c,
pubmed-meshheading:17567446-Enzyme Activation,
pubmed-meshheading:17567446-Fluorescent Dyes,
pubmed-meshheading:17567446-Humans,
pubmed-meshheading:17567446-Hydrogen Peroxide,
pubmed-meshheading:17567446-Membrane Potential, Mitochondrial,
pubmed-meshheading:17567446-Phosphatidylserines,
pubmed-meshheading:17567446-Reactive Oxygen Species,
pubmed-meshheading:17567446-Thrombin
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pubmed:year |
2007
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pubmed:articleTitle |
Thrombin induces apoptotic events through the generation of reactive oxygen species in human platelets.
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pubmed:affiliation |
Department of Physiology (Cellular Physiology Research Group), University of Extremadura, Cáceres, Spain.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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