Linked Life Data

17566734

Source:http://linkedlifedata.com/resource/pubmed/id/17566734

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2007-7-30
pubmed:abstractText
A series of nine 1-(4-((E)-3-arylacryloyl)phenyl)-1H-pyrrole-2,5-diones 3a-i (4'-aminochalcone-based maleimides) was synthesized as candidate cytotoxic agents. The efficacy of these potential cytotoxics were evaluated against three representative cell lines and more than half of the drug candidates proved to exhibit significant cytostatic activity in vitro. QSAR studies using statistical analyses on several physicochemical parameters and IC50 values resulted in a few very important correlations which will aid in later the amplification of the project. Representative test compounds were well tolerated by mice in in vivo survival and toxicity studies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0960-894X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4545-50
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Cytostatic activity of novel 4'-aminochalcone-based imides.
pubmed:affiliation
Department of Chemistry, Acadia University, Wolfville, NS, Canada B4P 2R6. ajha@acadiau.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't