Linked Life Data

17566295

Source:http://linkedlifedata.com/resource/pubmed/id/17566295

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-6-14
pubmed:abstractText
Although intracytoplasmic sperm injection (ICSI) is an innovative treatment for male infertility, a significant number of clinical cases of fertilization failure remain. ICSI overcomes the difficulty during fertilization of spermatozoon entry into the egg cytoplasm. The goal of fertilization, however, is the union of the male and female genomes; spermatozoon incorporation into the oocyte is only the initiation of fertilization. During fertilization in most mammalian species, including humans, the spermatozoon introduces the centrosome, which acts as a microtubule organizing center (MTOC). By promoting pronuclear apposition and mitotic spindle formation, the spermatozoon plays the leading part in the induction of "motility" post-ICSI in fertilization. The present review introduces the remaining challenges in functional assessment of the human sperm centrosome and discusses the biparental (for example, rabbit) and maternal (for example, parthenogenesis) centrosomal contributions to microtubule organization during development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:author
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
507-13
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Functional analyses of the sperm centrosome in human reproduction: implications for assisted reproductive technique.
pubmed:affiliation
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan. terada@mail.tains.tohoku.ac.jp
pubmed:publicationType
Journal Article, Review