|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
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|
pubmed:dateCreated |
2007-6-13
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|
pubmed:abstractText |
Systemic chemotherapy has not seen widespread use in the treatment for hepatocellular carcinoma (HCC). Recently, it was reported that combination treatment of 5-fluorouracil (5-FU) and interferon (IFN)-alpha was effective for non-resectable HCC. The effect of 5-FU treatment is influenced by the activities of pyrimidine catabolic enzymes. The aim of this study was to investigate which IFN-alphais most effective in combination therapy via downregulation of dihydropyrimidine dehydrogenase (DPD).
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pubmed:language |
jpn
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
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pubmed:issn |
0385-0684
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
34
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
957-9
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pubmed:meshHeading |
pubmed-meshheading:17565266-Antimetabolites, Antineoplastic,
pubmed-meshheading:17565266-Carcinoma, Hepatocellular,
pubmed-meshheading:17565266-Cell Division,
pubmed-meshheading:17565266-Cell Line, Tumor,
pubmed-meshheading:17565266-Dihydrouracil Dehydrogenase (NADP),
pubmed-meshheading:17565266-Down-Regulation,
pubmed-meshheading:17565266-Fluorouracil,
pubmed-meshheading:17565266-Humans,
pubmed-meshheading:17565266-Interferon-alpha,
pubmed-meshheading:17565266-Liver Neoplasms
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
[Anti-tumor effects of various interferons-alpha +5-fluorouracil via downregulation of dihydropyrimidine dehydrogenase in hepatoma cells].
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|
pubmed:affiliation |
Dept. of Surgery, Oita University Faculty of Medicine.
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|
pubmed:publicationType |
Journal Article,
English Abstract
|
