Source:http://linkedlifedata.com/resource/pubmed/id/17564953
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2007-7-10
|
| pubmed:abstractText |
Two new thiophenes, 5-{4-[4-(5-pent-1,3-diynylthiophen-2-yl)-but-3-ynyloxy]-but-1-ynyl}-2,2'-bithiophene (1) and 5-(4-hydroxybut-1-one)-2,2'-bithiophene (2), together with two known thiophenes 5-(4-hydroxybut-1-ynyl)-2,2'-bithiophene (3) and 5-(3,4-dihydroxybut-1-ynyl)-2,2'-bithiophene (4), were isolated from the roots of Echinops latifolius Tausch. Their structures were elucidated based on the detailed NMR spectroscopic analysis and comparison with literature values. Compounds 1 and 2 showed significant inhibition activities against human cancer cell lines A375-S2 and HeLa with IC(50) values from 3.1 to 13.5 micromol/L, depending on their exposure to long wavelength ultraviolet light.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0032-0943
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
73
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
696-8
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| pubmed:meshHeading |
pubmed-meshheading:17564953-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:17564953-Asteraceae,
pubmed-meshheading:17564953-Cell Line, Tumor,
pubmed-meshheading:17564953-Humans,
pubmed-meshheading:17564953-Inhibitory Concentration 50,
pubmed-meshheading:17564953-Phytotherapy,
pubmed-meshheading:17564953-Plant Extracts,
pubmed-meshheading:17564953-Plant Roots,
pubmed-meshheading:17564953-Thiophenes
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Two new thiophenes from Echinops latifolius and their phototoxic activities.
|
| pubmed:affiliation |
Research Department of Natural Medicine, Shenyang Pharmaceutical University, Shenyang, P.R. China.
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| pubmed:publicationType |
Journal Article
|