Linked Life Data

17564508

Source:http://linkedlifedata.com/resource/pubmed/id/17564508

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-6-13
pubmed:abstractText
The gene expression profile of a normal-suffering monozygotic twin pair is investigated to explore biological mechanisms of spastic type cerebral palsy. Main works include following three aspects: First, a cDNA microarray test is carried out to get the differentially expressed genes of the patient with cerebral palsy compared to her monozygotic twin sister. Second, these differentially expressed genes are searched for their bioinformation within 4 biological databases: FatiGO, FatiGOPlus, KEGG, and SOURCE. Third, a set of special genes and gene families are screened out from the spastic type cerebral palsy patient. These biological analyses reveal that those genes for cell junction are mostly down-regulated, while those genes for metabolism are mostly up-regulated. The individual genes, gene family, and their associated biological functions can reflect the pathological and physiological characteristics of the cerebral palsy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1832-4274
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
496-507
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Study of gene expression profiles and biological mechanism of cerebral palsy using a monozygotic twin pair.
pubmed:affiliation
Genetics Laboratory, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Twin Study