Source:http://linkedlifedata.com/resource/pubmed/id/17563456
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2007-6-12
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pubmed:abstractText |
Insulin resistance plays a significant role in both morbidity and mortality of the general population. Understanding the molecular mechanisms of insulin resistance would help the identification of at-risk individuals in the presymptomatic stage, and the discovery of novel and more effective treatments. The transmembrane glycoprotein ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) inhibits insulin receptor signalling and has recently emerged as a key player in the development of insulin resistance. This review will summarize data available on the relationship between ENPP1 and insulin resistance.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1363-1950
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
403-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17563456-Diabetes Mellitus, Type 2,
pubmed-meshheading:17563456-Genetic Linkage,
pubmed-meshheading:17563456-Humans,
pubmed-meshheading:17563456-Insulin Resistance,
pubmed-meshheading:17563456-Mutation, Missense,
pubmed-meshheading:17563456-Obesity,
pubmed-meshheading:17563456-Phosphoric Diester Hydrolases,
pubmed-meshheading:17563456-Polymorphism, Single Nucleotide,
pubmed-meshheading:17563456-Pyrophosphatases,
pubmed-meshheading:17563456-Signal Transduction
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pubmed:year |
2007
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pubmed:articleTitle |
ENPP1 gene, insulin resistance and related clinical outcomes.
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pubmed:affiliation |
Research Laboratory of Diabetes and Endocrine Diseases, CSS Scientific Institute, San Giovanni Rotondo, Italy.
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pubmed:publicationType |
Journal Article,
Review
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