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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2007-7-13
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pubmed:abstractText |
Spontaneous clearance of hepatitis C virus (HCV) has frequently been associated with the presence of HCV-specific cellular immunity. However, there had been also reports in chimpanzees demonstrating clearance of HCV-viremia in the absence of significant levels of detectable HCV-specific cellular immune responses. We here report seven asymptomatic acute hepatitis C cases with peak HCV-RNA levels between 300 and 100,000 copies/ml who all cleared HCV-RNA spontaneously. Patients were identified by a systematic screening of 1176 consecutive new incoming offenders in a German young offender institution. Four of the seven patients never developed anti-HCV antibodies and had normal ALT levels throughout follow-up. Transient weak HCV-specific CD4+ T cell responses were detectable in five individuals which did not differ in strength and breadth from age- and sex-matched patients with chronic hepatitis C and long-term recovered patients. In contrast, HCV-specific MHC-class-I-tetramer-positive cells were found in 3 of 4 HLA-A2-positive patients. Thus, these cases highlight that clearance of low levels of HCV viremia is possible in the absence of a strong adaptive immune response which might explain the low seroconversion rate after occupational exposure to HCV.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17562015-10229187,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1743-422X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
58
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pubmed:dateRevised |
2010-9-16
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pubmed:meshHeading |
pubmed-meshheading:17562015-Adolescent,
pubmed-meshheading:17562015-Adult,
pubmed-meshheading:17562015-Alanine Transaminase,
pubmed-meshheading:17562015-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17562015-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17562015-Hepacivirus,
pubmed-meshheading:17562015-Hepatitis C,
pubmed-meshheading:17562015-Hepatitis C Antibodies,
pubmed-meshheading:17562015-Humans,
pubmed-meshheading:17562015-Interferon-gamma,
pubmed-meshheading:17562015-Male,
pubmed-meshheading:17562015-RNA, Viral,
pubmed-meshheading:17562015-T-Lymphocyte Subsets,
pubmed-meshheading:17562015-Viremia
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pubmed:year |
2007
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pubmed:articleTitle |
Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response.
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pubmed:affiliation |
Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany. ManuelaF.Meyer@gmx.de
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pubmed:publicationType |
Journal Article
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