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rdf:type |
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lifeskim:mentions |
umls-concept:C0007102,
umls-concept:C0023688,
umls-concept:C0030685,
umls-concept:C0036536,
umls-concept:C0036537,
umls-concept:C0071174,
umls-concept:C0086418,
umls-concept:C0205263,
umls-concept:C0205374,
umls-concept:C0282639,
umls-concept:C0334227,
umls-concept:C0391871,
umls-concept:C0521451,
umls-concept:C0596019,
umls-concept:C0596235,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1522538,
umls-concept:C1823521,
umls-concept:C1963578
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pubmed:issue |
11
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pubmed:dateCreated |
2007-10-17
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pubmed:abstractText |
TSPO (translocator protein), known previously as PBR (peripheral-type benzodiazepine receptor), is a 18 kDa protein expressed in the mitochondrial membrane of a variety of tissues. TSPO has been reported to be over-expressed in human colorectal tumours and cancer cell lines, but its function is not well characterized.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5-nitro-2-(3-phenylpropylamino)benzo...,
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorides,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Flunitrazepam,
http://linkedlifedata.com/resource/pubmed/chemical/GABA Modulators,
http://linkedlifedata.com/resource/pubmed/chemical/Isoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrobenzoates,
http://linkedlifedata.com/resource/pubmed/chemical/PK 11195,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, GABA,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Potassium-Chloride Symporters,
http://linkedlifedata.com/resource/pubmed/chemical/TSPO protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1768-322X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
639-47
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pubmed:dateRevised |
2008-5-14
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pubmed:meshHeading |
pubmed-meshheading:17561806-Angiogenesis Inhibitors,
pubmed-meshheading:17561806-Antineoplastic Agents,
pubmed-meshheading:17561806-Calcium,
pubmed-meshheading:17561806-Cell Line, Tumor,
pubmed-meshheading:17561806-Chlorides,
pubmed-meshheading:17561806-Colonic Neoplasms,
pubmed-meshheading:17561806-Cyclosporine,
pubmed-meshheading:17561806-Enzyme Inhibitors,
pubmed-meshheading:17561806-Flunitrazepam,
pubmed-meshheading:17561806-GABA Modulators,
pubmed-meshheading:17561806-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17561806-Humans,
pubmed-meshheading:17561806-Isoquinolines,
pubmed-meshheading:17561806-Ligands,
pubmed-meshheading:17561806-Mitochondria,
pubmed-meshheading:17561806-Mitochondrial Membranes,
pubmed-meshheading:17561806-Mitochondrial Proteins,
pubmed-meshheading:17561806-Neoplasm Proteins,
pubmed-meshheading:17561806-Nitrobenzoates,
pubmed-meshheading:17561806-Receptors, GABA,
pubmed-meshheading:17561806-Sodium-Potassium-Chloride Symporters
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pubmed:year |
2007
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pubmed:articleTitle |
Translocator protein (18 kDa) ligand PK 11195 induces transient mitochondrial Ca2+ release leading to transepithelial Cl- secretion in HT-29 human colon cancer cells.
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pubmed:affiliation |
Inserm U773, Centre de Recherche Biomédicale Bichat Beaujon CRB3, Université Paris 7 Denis Diderot, F-75018 Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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