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rdf:type |
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lifeskim:mentions |
umls-concept:C0002520,
umls-concept:C0023688,
umls-concept:C0040880,
umls-concept:C0182400,
umls-concept:C0205314,
umls-concept:C0205460,
umls-concept:C0220781,
umls-concept:C0441655,
umls-concept:C0679622,
umls-concept:C0969702,
umls-concept:C1167622,
umls-concept:C1442750,
umls-concept:C1704675,
umls-concept:C1707689,
umls-concept:C1883254
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pubmed:issue |
15
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pubmed:dateCreated |
2007-7-10
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pubmed:abstractText |
Novel triazole amino acids were synthesized as probes to investigate ligand-protein binding interactions of the neutral amino acid transporter SN1. The bonding hypothesis to be tested was that the side chains of endogenous substrates are acting as H-bond acceptors. Although limited inhibition of (3)H-L-glutamine uptake by SN1 expressing oocytes was observed, the synthetic compounds show a trend that suggests a hydrogen bond interaction just outside the endogenous ligand binding pocket.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-10619430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-10660562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-11193715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-11331400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-11533292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-11533296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-11533315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-11742981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-11756489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-11850497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-11906817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-11980913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-12059969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-12528181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-12675927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-12969260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-1458910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-15795900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-16154153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-2569662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-2877174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17561393-2883593
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4163-6
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:17561393-Amino Acid Transport Systems, Neutral,
pubmed-meshheading:17561393-Amino Acids,
pubmed-meshheading:17561393-Animals,
pubmed-meshheading:17561393-Hydrogen Bonding,
pubmed-meshheading:17561393-Ligands,
pubmed-meshheading:17561393-Models, Molecular,
pubmed-meshheading:17561393-Molecular Probes,
pubmed-meshheading:17561393-Rats,
pubmed-meshheading:17561393-Triazoles,
pubmed-meshheading:17561393-Xenopus
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pubmed:year |
2007
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pubmed:articleTitle |
Design, synthesis, and biological activity of novel triazole amino acids used to probe binding interactions between ligand and neutral amino acid transport protein SN1.
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pubmed:affiliation |
NIH-COBRE Center for Structural and Functional Neuroscience, Department of Pharmaceutical and Biomedical Sciences, The University of Montana, Missoula, MT 59812, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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