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rdf:type |
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lifeskim:mentions |
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0028128,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0035820,
umls-concept:C0205042,
umls-concept:C0205263,
umls-concept:C0441712,
umls-concept:C0597277,
umls-concept:C0871261,
umls-concept:C1135183,
umls-concept:C1702051,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
1-2
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pubmed:dateCreated |
2007-8-6
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pubmed:abstractText |
Rat and mouse hemokinin-1(r/m hemokinin-1) is a recently described member of the tachykinin family whose cardiovascular functions are not fully understood. In this study, we investigated the mechanisms of the relaxing response induced by r/m hemokinin-1 in isolated porcine coronary arteries by using a specific antagonist of tachykinin NK(1) receptor (SR140333), a nitric oxide synthase inhibitor N(omega)-nitro-L-arginine (L-NNA), and 1H-[1,2,4] Oxadiazolo [4,3-a] quinoxalin-1-one (ODQ), a blocker of cGMP production. r/m Hemokinin-1 (10(-12)-10(-6 )M) evoked a marked endothelium-dependent vasodilatation (E(max)=121.12+/-10.6% and 91.79+/-2.39% in 10(-6) M PGF(2)alpha and 30 mM KCl precontracted arterial rings, respectively) of coronary arteries mediated by activation of endothelial tachykinin NK(1) receptors. Two components contributed to this r/m hemokinin-1-elicited vasodilatation, the first of which was endothelium-derived hyperpolarizing factor (EDHF), which played a major role. This EDHF was identified as a potassium current through certain kinds of potassium channels on the endothelial cell membrane of porcine coronary arteries. Specific antagonists of Ca(2+)-activated K(+) channels (dequalinium and clotrimazole) did not have an inhibitory effect on the r/m hemokinin-1-induced vasodilatation, whereas they did on the substance P-induced vasodilatation. When potassium ion efflux was impaired by a high K(+) concentration (30 mM) or removal of K(+) from the surroundings, NO synthesis was triggered by r/m hemokinin-1 to produce an equivalent EDHF (K(+))-independent vasorelaxation as a compensatory mechanism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1H-(1,2,4)oxadiazolo(4,3-a)quinoxali...,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Infective Agents, Local,
http://linkedlifedata.com/resource/pubmed/chemical/Clotrimazole,
http://linkedlifedata.com/resource/pubmed/chemical/Dequalinium,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotransmitter Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroarginine,
http://linkedlifedata.com/resource/pubmed/chemical/Oxadiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Quinoxalines,
http://linkedlifedata.com/resource/pubmed/chemical/Quinuclidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurokinin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin,
http://linkedlifedata.com/resource/pubmed/chemical/SR 140333,
http://linkedlifedata.com/resource/pubmed/chemical/Substance P,
http://linkedlifedata.com/resource/pubmed/chemical/Tac4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tachykinins,
http://linkedlifedata.com/resource/pubmed/chemical/Tetraethylammonium,
http://linkedlifedata.com/resource/pubmed/chemical/prostaglandin F2alpha receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
569
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
119-25
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pubmed:meshHeading |
pubmed-meshheading:17560993-Animals,
pubmed-meshheading:17560993-Anti-Infective Agents, Local,
pubmed-meshheading:17560993-Clotrimazole,
pubmed-meshheading:17560993-Coronary Vessels,
pubmed-meshheading:17560993-Dequalinium,
pubmed-meshheading:17560993-Dose-Response Relationship, Drug,
pubmed-meshheading:17560993-Endothelium, Vascular,
pubmed-meshheading:17560993-Enzyme Inhibitors,
pubmed-meshheading:17560993-Mice,
pubmed-meshheading:17560993-Neurotransmitter Agents,
pubmed-meshheading:17560993-Nitric Oxide,
pubmed-meshheading:17560993-Nitroarginine,
pubmed-meshheading:17560993-Oxadiazoles,
pubmed-meshheading:17560993-Piperidines,
pubmed-meshheading:17560993-Potassium,
pubmed-meshheading:17560993-Potassium Channel Blockers,
pubmed-meshheading:17560993-Protein Precursors,
pubmed-meshheading:17560993-Quinoxalines,
pubmed-meshheading:17560993-Quinuclidines,
pubmed-meshheading:17560993-Rats,
pubmed-meshheading:17560993-Receptors, Neurokinin-1,
pubmed-meshheading:17560993-Receptors, Prostaglandin,
pubmed-meshheading:17560993-Substance P,
pubmed-meshheading:17560993-Swine,
pubmed-meshheading:17560993-Tachykinins,
pubmed-meshheading:17560993-Tetraethylammonium,
pubmed-meshheading:17560993-Vasodilation
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pubmed:year |
2007
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pubmed:articleTitle |
Mechanisms of relaxing response induced by rat/mouse hemokinin-1 in porcine coronary arteries: roles of potassium ion and nitric oxide.
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pubmed:affiliation |
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, Lanzhou University, 222 Tianshui South Road, Lanzhou, 730000, PR China.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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