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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-6-18
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pubmed:abstractText |
Histone deacetylase inhibitors (HDACi) induce growth arrest and differentiation, particularly in the colon where they are potential chemotherapeutic agents. A key mediator of HDACi action is the cyclin dependent kinase (CDK) inhibitor p21(waf1). HDACi treatment of colonic cells promotes the formation of an ATM/ZBP-89/p300 complex on p21(waf1) proximal promoter, and this multi-molecular complex plays an important role in HDACi induction of p21(waf1) expression in vitro and mucosal protection in vivo. Here we found that ZBP-89 is phosphorylated by ATM kinase in vitro and in vivo. Disruption of the ATM phosphorylation motif (202)SQ within the zinc finger domain of ZBP-89 attenuated its ability to enhance p21(waf1) activation by butyrate. Moreover, disruption of the ATM phosphorylation site abrogated the ability of ZBP-89 to potentiate butyrate induction of endogenous p21(waf1) expression. These results demonstrate that ATM phosphorylation of ZBP-89 contributes to HDACi induction of p21(waf1) gene expression.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-10625687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-10858953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-10899165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-11126357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-11252893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-11416144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-12524542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-12556884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-12782595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-12840224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-12840228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-14991611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-15051851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-16952553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-17320506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-3322397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-3667583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-6174854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-649576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-667927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-667928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-8386131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-8703954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-8723390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-9144414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-9384528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17560543-9437648
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Butyrates,
http://linkedlifedata.com/resource/pubmed/chemical/CDKN1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxamic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoserine,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ZNF148 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Zfp148 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Znf148 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/ataxia telangiectasia mutated...,
http://linkedlifedata.com/resource/pubmed/chemical/trichostatin A
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
359
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
817-21
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:17560543-Animals,
pubmed-meshheading:17560543-Butyrates,
pubmed-meshheading:17560543-Cell Cycle Proteins,
pubmed-meshheading:17560543-Cell Line,
pubmed-meshheading:17560543-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:17560543-DNA-Binding Proteins,
pubmed-meshheading:17560543-Gene Expression Regulation,
pubmed-meshheading:17560543-Humans,
pubmed-meshheading:17560543-Hydroxamic Acids,
pubmed-meshheading:17560543-Phosphoserine,
pubmed-meshheading:17560543-Protein-Serine-Threonine Kinases,
pubmed-meshheading:17560543-Transcription Factors,
pubmed-meshheading:17560543-Tumor Suppressor Protein p53,
pubmed-meshheading:17560543-Tumor Suppressor Proteins
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pubmed:year |
2007
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pubmed:articleTitle |
ATM phosphorylates ZBP-89 at Ser202 to potentiate p21waf1 induction by butyrate.
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pubmed:affiliation |
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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