rdf:type |
|
lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2007-7-30
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pubmed:abstractText |
AML1-ETO fusion protein is a product of chromosome translocation t(8;21) frequently occurred in acute myeloid leukemia (AML), but its sole expression appears to fail to cause overt leukemia in vivo. In this study, we investigated whether AML1-ETO expression impinged on action of chemical carcinogens-DNA adduct formation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Core Binding Factor Alpha 2 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A1,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Adducts,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RUNX1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RUNX1T1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0301-472X
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1249-55
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pubmed:meshHeading |
pubmed-meshheading:17560011-Carcinogens,
pubmed-meshheading:17560011-Cell Line, Tumor,
pubmed-meshheading:17560011-Core Binding Factor Alpha 2 Subunit,
pubmed-meshheading:17560011-Cytochrome P-450 CYP1A1,
pubmed-meshheading:17560011-DNA Adducts,
pubmed-meshheading:17560011-DNA-Binding Proteins,
pubmed-meshheading:17560011-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:17560011-Humans,
pubmed-meshheading:17560011-Leukemia,
pubmed-meshheading:17560011-Proto-Oncogene Proteins,
pubmed-meshheading:17560011-Recombinant Fusion Proteins,
pubmed-meshheading:17560011-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17560011-Transcription Factors,
pubmed-meshheading:17560011-U937 Cells
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pubmed:year |
2007
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pubmed:articleTitle |
Leukemogenic AML1-ETO fusion protein increases carcinogen-DNA adduct formation with upregulated expression of cytochrome P450-1A1 gene.
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pubmed:affiliation |
Institute of Health Science, Shanghai Jiao-Tong University School of Medicine/Shanghai Institutes of Biological Sciences and School of Graduate, Chinese Academy of Sciences, Shanghai, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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