pubmed-article:17557919 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17557919 | lifeskim:mentions | umls-concept:C0684336 | lld:lifeskim |
pubmed-article:17557919 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
pubmed-article:17557919 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
pubmed-article:17557919 | lifeskim:mentions | umls-concept:C0034785 | lld:lifeskim |
pubmed-article:17557919 | lifeskim:mentions | umls-concept:C0001645 | lld:lifeskim |
pubmed-article:17557919 | lifeskim:mentions | umls-concept:C0015259 | lld:lifeskim |
pubmed-article:17557919 | lifeskim:mentions | umls-concept:C0220931 | lld:lifeskim |
pubmed-article:17557919 | lifeskim:mentions | umls-concept:C1514762 | lld:lifeskim |
pubmed-article:17557919 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
pubmed-article:17557919 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
pubmed-article:17557919 | lifeskim:mentions | umls-concept:C0599756 | lld:lifeskim |
pubmed-article:17557919 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:17557919 | pubmed:dateCreated | 2007-9-6 | lld:pubmed |
pubmed-article:17557919 | pubmed:abstractText | Cardiac beta-adrenergic receptor (beta-AR) signaling and left ventricular (LV) responses to beta-AR stimulation are impaired with aging. It is shown that exercise and beta-AR blockade have a favorable effect on cardiac and vascular beta-AR signaling in several cardiovascular diseases. In the present study, we examined the effects of these two different strategies on beta-AR dysregulation and LV inotropic reserve in the aging heart. Forty male Wistar-Kyoto aged rats were randomized to sedentary, exercise (12 wk treadmill training), metoprolol (250 mg.kg(-1).day(-1) for 4 wk), and exercise plus metoprolol treatment protocols. Ten male Wistar-Kyoto sedentary young rats were also used as a control group. Old trained, old metoprolol-treated, and old trained plus metoprolol-treated rats showed significantly improved LV maximal and minimal first derivative of the pressure rise responses to beta-AR stimulation (isoproterenol) compared with old untrained animals. We found a significant reduction in cardiac sarcolemmal membrane beta-AR density and adenylyl cyclase activity in old untrained animals compared with young controls. Exercise training and metoprolol, alone or combined, restored cardiac beta-AR density and G-protein-dependent adenylyl cyclase activation in old rats. Although cardiac membrane G-protein-receptor kinase 2 levels were not upregulated in untrained old compared with young control rats, both exercise and metoprolol treatment resulted in a dramatic reduction of G-protein-receptor kinase 2 protein levels, which is a further indication of beta-AR signaling amelioration in the aged heart induced by these treatment modalities. In conclusion, we demonstrate for the first time that exercise and beta-AR blockade can similarly ameliorate beta-AR signaling in the aged heart, leading to improved beta-AR responsiveness and corresponding LV inotropic reserve. | lld:pubmed |
pubmed-article:17557919 | pubmed:language | eng | lld:pubmed |
pubmed-article:17557919 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17557919 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:17557919 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17557919 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17557919 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17557919 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17557919 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17557919 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17557919 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17557919 | pubmed:month | Sep | lld:pubmed |
pubmed-article:17557919 | pubmed:issn | 0363-6135 | lld:pubmed |
pubmed-article:17557919 | pubmed:author | pubmed-author:EspositoGiova... | lld:pubmed |
pubmed-article:17557919 | pubmed:author | pubmed-author:RapacciuoloAn... | lld:pubmed |
pubmed-article:17557919 | pubmed:author | pubmed-author:KochWalter... | lld:pubmed |
pubmed-article:17557919 | pubmed:author | pubmed-author:RengoFrancoF | lld:pubmed |
pubmed-article:17557919 | pubmed:author | pubmed-author:FerraraNicola... | lld:pubmed |
pubmed-article:17557919 | pubmed:author | pubmed-author:Lymperopoulos... | lld:pubmed |
pubmed-article:17557919 | pubmed:author | pubmed-author:IaccarinoGuid... | lld:pubmed |
pubmed-article:17557919 | pubmed:author | pubmed-author:RinaldiBarbar... | lld:pubmed |
pubmed-article:17557919 | pubmed:author | pubmed-author:FilippelliAme... | lld:pubmed |
pubmed-article:17557919 | pubmed:author | pubmed-author:LeoscoDarioD | lld:pubmed |
pubmed-article:17557919 | pubmed:author | pubmed-author:ZincarelliCar... | lld:pubmed |
pubmed-article:17557919 | pubmed:author | pubmed-author:RengoGiuseppe... | lld:pubmed |
pubmed-article:17557919 | pubmed:author | pubmed-author:GolinoLucaL | lld:pubmed |
pubmed-article:17557919 | pubmed:author | pubmed-author:FortunatoFran... | lld:pubmed |
pubmed-article:17557919 | pubmed:author | pubmed-author:MarcheseMassi... | lld:pubmed |
pubmed-article:17557919 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:17557919 | pubmed:volume | 293 | lld:pubmed |
pubmed-article:17557919 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:17557919 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:17557919 | pubmed:pagination | H1596-603 | lld:pubmed |
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pubmed-article:17557919 | pubmed:year | 2007 | lld:pubmed |
pubmed-article:17557919 | pubmed:articleTitle | Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation. | lld:pubmed |
pubmed-article:17557919 | pubmed:affiliation | Department of Internal Medicine, Cardiovascular Sciences and Immunology, University Federico II, Via Pansini 5, Edificio 2, 80131 Naples, Italy. dleosco@unina.it | lld:pubmed |
pubmed-article:17557919 | pubmed:publicationType | Journal Article | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17557919 | lld:pubmed |