Source:http://linkedlifedata.com/resource/pubmed/id/17557919
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2007-9-6
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| pubmed:abstractText |
Cardiac beta-adrenergic receptor (beta-AR) signaling and left ventricular (LV) responses to beta-AR stimulation are impaired with aging. It is shown that exercise and beta-AR blockade have a favorable effect on cardiac and vascular beta-AR signaling in several cardiovascular diseases. In the present study, we examined the effects of these two different strategies on beta-AR dysregulation and LV inotropic reserve in the aging heart. Forty male Wistar-Kyoto aged rats were randomized to sedentary, exercise (12 wk treadmill training), metoprolol (250 mg.kg(-1).day(-1) for 4 wk), and exercise plus metoprolol treatment protocols. Ten male Wistar-Kyoto sedentary young rats were also used as a control group. Old trained, old metoprolol-treated, and old trained plus metoprolol-treated rats showed significantly improved LV maximal and minimal first derivative of the pressure rise responses to beta-AR stimulation (isoproterenol) compared with old untrained animals. We found a significant reduction in cardiac sarcolemmal membrane beta-AR density and adenylyl cyclase activity in old untrained animals compared with young controls. Exercise training and metoprolol, alone or combined, restored cardiac beta-AR density and G-protein-dependent adenylyl cyclase activation in old rats. Although cardiac membrane G-protein-receptor kinase 2 levels were not upregulated in untrained old compared with young control rats, both exercise and metoprolol treatment resulted in a dramatic reduction of G-protein-receptor kinase 2 protein levels, which is a further indication of beta-AR signaling amelioration in the aged heart induced by these treatment modalities. In conclusion, we demonstrate for the first time that exercise and beta-AR blockade can similarly ameliorate beta-AR signaling in the aged heart, leading to improved beta-AR responsiveness and corresponding LV inotropic reserve.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol,
http://linkedlifedata.com/resource/pubmed/chemical/Metoprolol,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0363-6135
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| pubmed:author |
pubmed-author:EspositoGiovanniG,
pubmed-author:FerraraNicolaN,
pubmed-author:FilippelliAmeliaA,
pubmed-author:FortunatoFrancescaF,
pubmed-author:GolinoLucaL,
pubmed-author:IaccarinoGuidoG,
pubmed-author:KochWalter JWJ,
pubmed-author:LeoscoDarioD,
pubmed-author:LymperopoulosAnastasiosA,
pubmed-author:MarcheseMassimoM,
pubmed-author:RapacciuoloAntonioA,
pubmed-author:RengoFrancoF,
pubmed-author:RengoGiuseppeG,
pubmed-author:RinaldiBarbaraB,
pubmed-author:ZincarelliCarmelaC
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| pubmed:issnType |
Print
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| pubmed:volume |
293
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
H1596-603
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| pubmed:meshHeading |
pubmed-meshheading:17557919-Adenylate Cyclase,
pubmed-meshheading:17557919-Adrenergic beta-Agonists,
pubmed-meshheading:17557919-Adrenergic beta-Antagonists,
pubmed-meshheading:17557919-Aging,
pubmed-meshheading:17557919-Animals,
pubmed-meshheading:17557919-Blood Pressure,
pubmed-meshheading:17557919-Heart,
pubmed-meshheading:17557919-Heart Rate,
pubmed-meshheading:17557919-Isoproterenol,
pubmed-meshheading:17557919-Male,
pubmed-meshheading:17557919-Metoprolol,
pubmed-meshheading:17557919-Myocardial Contraction,
pubmed-meshheading:17557919-Physical Conditioning, Animal,
pubmed-meshheading:17557919-Random Allocation,
pubmed-meshheading:17557919-Rats,
pubmed-meshheading:17557919-Rats, Inbred WKY,
pubmed-meshheading:17557919-Receptors, Adrenergic, beta,
pubmed-meshheading:17557919-Signal Transduction,
pubmed-meshheading:17557919-Ventricular Function, Left
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| pubmed:year |
2007
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| pubmed:articleTitle |
Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation.
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| pubmed:affiliation |
Department of Internal Medicine, Cardiovascular Sciences and Immunology, University Federico II, Via Pansini 5, Edificio 2, 80131 Naples, Italy. dleosco@unina.it
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| pubmed:publicationType |
Journal Article
|