Source:http://linkedlifedata.com/resource/pubmed/id/17557277
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2007-9-25
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pubmed:abstractText |
Chinese Hamster Ovary fibroblasts (CHO-K1) have shown different protein contents when undergoing differentiation by 3',5'-cyclic adenosine monophosphate (cAMP), which is known to induce reverse transformation (RT) from malignancy to fibroblast-like characteristics. The mass spectrometry (MS) investigation here reported about the behavior of CHO-K1 cells before and after exposure to cAMP reveals a change in the composition of nuclear proteins associated to an inhibition of the protein expression. Possible implications of this finding on the control of cell reverse transformation are discussed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0730-2312
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
473-82
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pubmed:meshHeading |
pubmed-meshheading:17557277-Animals,
pubmed-meshheading:17557277-CHO Cells,
pubmed-meshheading:17557277-Chromatography, High Pressure Liquid,
pubmed-meshheading:17557277-Cricetinae,
pubmed-meshheading:17557277-Cricetulus,
pubmed-meshheading:17557277-Cyclic AMP,
pubmed-meshheading:17557277-Nuclear Envelope,
pubmed-meshheading:17557277-Nuclear Proteins,
pubmed-meshheading:17557277-Spectrometry, Mass, Electrospray Ionization
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pubmed:year |
2007
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pubmed:articleTitle |
cAMP induced alterations of Chinese hamster ovary cells monitored by mass spectrometry.
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pubmed:affiliation |
Nanoworld Institute-CIRSDNNOB, and Eminent Chair of Biophysics, Genova University, Corso Europa 30, 16132 Genova, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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