Linked Life Data

17557123

Source:http://linkedlifedata.com/resource/pubmed/id/17557123

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-8-3
pubmed:abstractText
The appendicular skeletons of high [C3H/HeJ (C3H)] and low [C57BL/6J (B6)] density inbred mice have been shown to differ in morphology, mechanical properties, and cellular activity. The focus of the current study was to (1) characterize the mandibular bone formation rate (BFR/BS), bone mass, indentation modulus (IM), and hardness of C3H and B6 mice and (2) investigate the relationship of the mechanical properties in three skeletal sites: mandible, femur, and tibia. Specimens from 17-week-old female C3H and B6 (n = 15/group) mice were obtained. Mandibular bone mass was estimated from the lateral-view area (LVA) and transverse cross sections. BFR/BS was measured in the mandibular section distal to the third molar. In addition, bone blocks from the distal surface of the third molar and the femoral and tibial midshaft were obtained for mechanical testing. BFR/BS, cortical area, and LVA were greater (P < 0.001) in C3H mandibles. IM was approximately 2 GPa higher in the C3H mandible (P > 0.05), femur (P < 0.001), and tibia (P < 0.01). Mandibular IM was lower (P < 0.05) than the femoral and tibial IM within each inbred mouse. IM was not significant between C3H and B6 mandibles. However, the magnitude of the difference ( approximately 12%) in the mandible was similar to the difference in the appendicular skeleton. This mandibular bone phenotype is similar to that observed in the appendicular skeleton of these distinct inbred mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0171-967X
pubmed:author
pubmed:issnType
Print
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
107-13
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Adaptations in the mandible and appendicular skeleton of high and low bone density inbred mice.
pubmed:affiliation
Section of Oral Biology, College of Dentistry, The Ohio State University, 3188 Postel Hall, 305 W. 12th Avenue, Columbus, OH, 43210, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't