| pubmed-article:17556586 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17556586 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:17556586 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17556586 | lifeskim:mentions | umls-concept:C0007194 | lld:lifeskim |
| pubmed-article:17556586 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17556586 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:17556586 | pubmed:issue | 5830 | lld:pubmed |
| pubmed-article:17556586 | pubmed:dateCreated | 2007-6-8 | lld:pubmed |
| pubmed-article:17556586 | pubmed:abstractText | We describe a sensitive mRNA profiling technology, PMAGE (for "polony multiplex analysis of gene expression"), which detects messenger RNAs (mRNAs) as rare as one transcript per three cells. PMAGE incorporates an improved ligation-based method to sequence 14-nucleotide tags derived from individual mRNA molecules. One sequence tag from each mRNA molecule is amplified onto a separate 1-micrometer bead, denoted as a polymerase colony or polony, and about 5 million polonies are arrayed in a flow cell for parallel sequencing. Using PMAGE, we identified early transcriptional changes that preceded pathological manifestations of hypertrophic cardiomyopathy in mice carrying a disease-causing mutation. PMAGE provided a comprehensive profile of cardiac mRNAs, including low-abundance mRNAs encoding signaling molecules and transcription factors that are likely to participate in disease pathogenesis. | lld:pubmed |
| pubmed-article:17556586 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17556586 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17556586 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17556586 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17556586 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:17556586 | pubmed:issn | 1095-9203 | lld:pubmed |
| pubmed-article:17556586 | pubmed:author | pubmed-author:SeidmanJ GJG | lld:pubmed |
| pubmed-article:17556586 | pubmed:author | pubmed-author:ChurchGeorge... | lld:pubmed |
| pubmed-article:17556586 | pubmed:author | pubmed-author:SeidmanChrist... | lld:pubmed |
| pubmed-article:17556586 | pubmed:author | pubmed-author:KimJae BumJB | lld:pubmed |
| pubmed-article:17556586 | pubmed:author | pubmed-author:LeiSongS | lld:pubmed |
| pubmed-article:17556586 | pubmed:author | pubmed-author:GorhamJoshua... | lld:pubmed |
| pubmed-article:17556586 | pubmed:author | pubmed-author:PorrecaGregor... | lld:pubmed |
| pubmed-article:17556586 | pubmed:author | pubmed-author:GreenwaySteve... | lld:pubmed |
| pubmed-article:17556586 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17556586 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:17556586 | pubmed:volume | 316 | lld:pubmed |
| pubmed-article:17556586 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17556586 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17556586 | pubmed:pagination | 1481-4 | lld:pubmed |
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| pubmed-article:17556586 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17556586 | pubmed:articleTitle | Polony multiplex analysis of gene expression (PMAGE) in mouse hypertrophic cardiomyopathy. | lld:pubmed |
| pubmed-article:17556586 | pubmed:affiliation | Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:17556586 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17556586 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17556586 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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