Linked Life Data

17554832

Source:http://linkedlifedata.com/resource/pubmed/id/17554832

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6 Pt 1
pubmed:dateCreated
2007-6-7
pubmed:abstractText
Regenerative electrodes are designed to interface regenerated axons from a sectioned peripheral nerve. Applicability of regenerative electrodes depends on biocompatibility, success of axonal regeneration, secondary nerve damage, and adequacy of interface electronics. Polyimide sieve electrodes with 281 holes were chronically implanted in the severed sciatic nerve of 30 rats. Regeneration was successful in all the animals, with increasing numbers of regenerated myelinated fibers from 2 to 6 mo. However, constrictive axonopathy affected a few cases from 6 to 12 mo. postimplantation. A second electrode design with 571 holes and 27 ring electrodes was developed. The number of regenerated axons increased thanks to the larger open area. Recordings were obtained from a low proportion of electrodes on the sieve in response to distal stimulation. Difficulties for recording impulses with regenerative electrodes include the small size of regenerated axons, changes in membrane excitability and in target reconnection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0018-9294
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1129-37
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Neurobiological assessment of regenerative electrodes for bidirectional interfacing injured peripheral nerves.
pubmed:affiliation
Institute of Neurosciences, Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Spain. natalia.lago@uab.es
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't